Chemo II Quiz Flashcards
A 30 y/o woman underwent segmental mastectomy for abreast tumor of 3 cm diameter. Lymph node sampling revealed 2 involved nodes. Because chemo is of established value in her situation, she underwent postop treatment with antineoplastic drugs. The regimen consisted of doxorubicin followed by cyclophosphamide/methotrexate/fluorouracil. Adjunctive drugs included tamoxifen because the tumor cells were hormone receptor-positive.
The chemo caused acute hemorrhagic cystitis. Which drug was most likely responsible for this toxicity?
Tamoxifen
Cyclophosphamide
Methotrexate
Fluorouracil
Cyclophosphamide
After several cycles of chemo, the above patient was found to have a high resting pulse rate. A radionuclide scan revealed evidence of cardiomyopathy. The drug that is most likely responsible for the cardiac toxicity is
Tamoxifen
Cyclophosphamide
Doxorubicin
Methotrexate
Doxorubicin
An adult is treated for acute leukemia with a combination that includes cyclophosphamide, mercaptopurine, methotrexate, vincristine, and prednisone. He is also using ondansetron for emesis, a chlorhexidine mouthwash to reduce mucositis, and laxatives. The patient complains of pins and needle sensations in the extremities and muscle weakness. He is not able to execute a deep knee bend or get up out of a chair without using his arm muscles. He is also very constipated. If these problems are related to the chemo, which of the following is most likely the causative agent?
Cyclophosphamide
Vincristine
Methotrexate
Ondansetron
Vincristine
Which of the following drugs used in combination therapy for testicular carcinoma is also associated with nephrotoxicity?
Bleomycin
Cisplatin
Etoposide
Vinblastine
Cisplatin
During the second course of drug treatment (ABVD regimen), a patient developed dyspnea, a nonproductive cough, and intermittent fever. Chest x-ray revealed pulmonary infiltration. If these problems are due to chemo, which is the most likely causative agent?
Bleomycin
Doxorubicin
Vinblastine
Prednisone
Bleomycin
