chemo gi problems Flashcards

1
Q

risk factor of cinv: age?

A

less than 50yo

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2
Q

rf for cinv: gender

A

female

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3
Q

iv high mod low risk

A

high >90%
moderate > 30-90%
low 10-30%

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4
Q

PO mod to high risk; low to moderate risk

A

> 30% freq / <30%

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5
Q

PO aprepitant dose day 1

A

125 mg

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6
Q

ondansetron dose

A

8-16mg

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7
Q

granisetron dose

A

1 mg

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8
Q

dexa day 1 dose

A

12 mg od

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9
Q

dexa day 2 dose

A

8 mg od

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10
Q

high risk day 1 drug regimen

A

akynzeo + dexa

OR

aprepitant + ondansetron + dexa

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11
Q

olz dose

A

5mg (2.5mg for elderly)

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12
Q

moderate intensity day 1

A

ondansetron + dexa

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13
Q

low risk day 1

A

ondansetron or dexa or metocloperamide

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14
Q

day 2 high risk

A

8 mg OD

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15
Q

po aprepitant day 2/3

A

80 mg OD

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16
Q

agents for both acute and delayed therapy

A

nk1 antagonist
dexa
atypical antipsych

17
Q

agents for only acute therapy

A

ondansetron / metocloperamide

18
Q

bzd used for

A

anticipatory cv

19
Q

haloperidol dose for refractory cinv

A

po 0.5-2mg q4-6

20
Q

uncomplicated diarrhoea tx

A

po loperamide 4mg, then 2mg q4h or after every diarrhoea. until 12h diarrhoea free

21
Q

complicated diarrhoea tx

A

sq octreotide 100-150 tds, can increase 50mg q24hrly

add on cipro 500mg 7d

22
Q

diarrhoea age rf

A

above 65

23
Q

diarrhoea rf ecog status

A

at least 2

24
Q

other rf of cid

A

bowel malignancy/inflammation
first chemo cycle
cycle dx at least 3 weeks
concomittant neutropenia
vomiting anorexia anemia

25
Q

grade 1 cid

A

<4 stools per day above baseline

26
Q

grade 2 cid

A

4-6 stools per day above baseline

27
Q

grade 3

A

at least 7 stools per day abv baseline

hospitalisation needed

28
Q

octreotide moa

A

decreases fluid secretion and increases fluid absorption

29
Q

octreotide se

A

bradycardia, arrhythmia, enlarged thyroid, nv

30
Q

irinotecan associated diarrhoea early prevention and tx

A

sc atropine 0.25-1mg

31
Q

irinocetan assiociate diarrhoea late tx

A

loperamide 4 mg then 2mg q2h until 12h diarrhoea

32
Q

nk1 antagonist ddi

A

steroids, warfarin, bzd, ifosfamide