chemo gi problems

Question 1

risk factor of cinv: age?

Answer 1

less than 50yo

Question 2

rf for cinv: gender

Answer 2

female

Question 3

iv high mod low risk

Answer 3

high >90%
moderate > 30-90%
low 10-30%

Question 4

PO mod to high risk; low to moderate risk

Answer 4

> 30% freq / <30%

Question 5

PO aprepitant dose day 1

Answer 5

125 mg

Question 6

ondansetron dose

Answer 6

8-16mg

Question 7

granisetron dose

Answer 7

1 mg

Question 8

dexa day 1 dose

Answer 8

12 mg od

Question 9

dexa day 2 dose

Answer 9

8 mg od

Question 10

high risk day 1 drug regimen

Answer 10

akynzeo + dexa

OR

aprepitant + ondansetron + dexa

Question 11

olz dose

Answer 11

5mg (2.5mg for elderly)

Question 12

moderate intensity day 1

Answer 12

ondansetron + dexa

Question 13

low risk day 1

Answer 13

ondansetron or dexa or metocloperamide

Question 14

day 2 high risk

Answer 14

8 mg OD

Question 15

po aprepitant day 2/3

Answer 15

80 mg OD

Question 16

agents for both acute and delayed therapy

Answer 16

nk1 antagonist
dexa
atypical antipsych

Question 17

agents for only acute therapy

Answer 17

ondansetron / metocloperamide

Question 18

bzd used for

Answer 18

anticipatory cv

Question 19

haloperidol dose for refractory cinv

Answer 19

po 0.5-2mg q4-6

Question 20

uncomplicated diarrhoea tx

Answer 20

po loperamide 4mg, then 2mg q4h or after every diarrhoea. until 12h diarrhoea free

Question 21

complicated diarrhoea tx

Answer 21

sq octreotide 100-150 tds, can increase 50mg q24hrly

add on cipro 500mg 7d

Question 22

diarrhoea age rf

Answer 22

above 65

Question 23

diarrhoea rf ecog status

Answer 23

at least 2

Question 24

other rf of cid

Answer 24

bowel malignancy/inflammation
first chemo cycle
cycle dx at least 3 weeks
concomittant neutropenia
vomiting anorexia anemia

Question 25

grade 1 cid

Answer 25

<4 stools per day above baseline

Question 26

grade 2 cid

Answer 26

4-6 stools per day above baseline

Question 27

grade 3

Answer 27

at least 7 stools per day abv baseline

hospitalisation needed

Question 28

octreotide moa

Answer 28

decreases fluid secretion and increases fluid absorption

Question 29

octreotide se

Answer 29

bradycardia, arrhythmia, enlarged thyroid, nv

Question 30

irinotecan associated diarrhoea early prevention and tx

Answer 30

sc atropine 0.25-1mg

Question 31

irinocetan assiociate diarrhoea late tx

Answer 31

loperamide 4 mg then 2mg q2h until 12h diarrhoea

Question 32

nk1 antagonist ddi

Answer 32

steroids, warfarin, bzd, ifosfamide