Chemo Drugs Flashcards

1
Q

Vidaza

IV

A
For bone marrow and blood cancers
Antimetabolite
Route: IV
Side Effects: decreased vitamin K levels
n/v/d/f
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2
Q

Vectibix

IV

A

For metastatic colon cancer
Monoclonal EGFR sensitive
Side Effect: D/low magnesium

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3
Q

Sutent

(oral)

A

GIST, renal pancreatic, neuroendrocrine
Protein Targeted therapy
SE: n/v/d/decreased appetite, hand-foot sx, rash, can turn hair white
NO GRAPEFRUIT

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4
Q

Epirubin (Ellence)

IV

A

Breast
Antitumor ATB- Cell Cycle Specific
SE: N/V/D/mucositis/rash

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5
Q

Gemzar

IV

A

Pancreatic/bladder/breast/ovarian/lung
Antimetabolite-Cell Cycle Specific (pyrimide antagonist)
SE: n/v/pulmonary/flu like sx/clay colored stools

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6
Q

Cytoxan (cyclophosphamide)

IV

A
Breast, ovarian, CLL, lymphomas
Alkylating Agent (non cell cycle specific)
SE: BLADDER TOXICITY, N/v
PUSH FLUIDS
Give Mensa to prevent bleeding cysts
Can increase effect of anticoagulants
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7
Q

Taxol (paclitaxel)

IV

A
bladder, breast, ovarian, H&N, Esophageal, lung, prostate pancreatic
Plant Alkaloid(taxane)
SE: diarrhea/Mucositis
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8
Q

Doxil (doxorubin liposomal)

IV

A

Metastatic ovarian, Kaposi’s, breast
Antitumor ATB
SE: n/v/d/mucositis, hand foot sx
turns urine red

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9
Q

Adriamycin(doxorubin)

IV

A

breast, gastric, HN, lung, liver, kidney ALL and many more
Anthracycline ATB
SE: n/v/d/mucositis/hand foot sx, anorexia, “red devil”
Give Omega 3s/CoQ 10/Theanine- may reduce toxicity

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10
Q

Vinorelbine(navelbine)

IV

A

breast, ovarian, lung
Plant alkaloid
SE: constipation, stomatitis
a/n/v

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11
Q

Etoposide

IV

A

lung, gastric, testicular, bladder prostate
Plant Alkaloid (cell cycle specific)
SE: Metallic taste, a/n/v/d

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12
Q

Herceptin (Trastuzumab)

IV

A

metastatic breast cancer HER2/NEU
Monoclonol ATB
SE: n/v/d
avocados, olive oil increase sensitivity to drug

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13
Q

xgeva (denosumab)

injection

A

To prevent skeletal related events
Monocolonal ATB RANK inhibitor
SE: n/v/d, decreased Calcium
Osteonecrosis of jaw

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14
Q

Carboplatin (paraplatin)

IV

A

HN, bladder, ovarian, lung endo
Alkylating agent
SE: n/v, peripheral neuropathy

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15
Q

Treanda (bendamustine)

IV

A

CLL, NHL
Alkylating agent
SE: n/v/f
Tumor lysis syndrome

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16
Q

Iressa

oral

A

NSCLC
Protein target tx- tyrosine kinase inhibitor EGFR
SE: n/v/d, decrease appetite, hand-foot sx
Take with WATER

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17
Q

Kadcyla

IV

A

HER2+ metastatic breast
Monoclonal ATB
SE: Constipation, increased liver enzymes, n/f

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18
Q

List 3 Aromatase Inhibitors

A

Anastrozenole (Arimidex)
Aromasin(exemestane)
Femara
SE: hot flashes, fatigue, joint pain, blood clots, muscle aches, elev. chol, BONE LOSS
AntiEstrogens
Counsel to promote bone strength (calcium, vit D, exercise)

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19
Q

Zometa

IV

A

bone mets

Need 500 mg Calcium and 400 IU Vit D daily

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20
Q

Vincristine (oncovin)

IV

A

leukemia, lymphoma, Multiple Myeloma, brain
Plant Alkaloid (cell cycle specific)
SE: SEVERE CONSTIPATION, Jaw pain, decreased appetite
AVOID: SJ WORT, GRAPEFRUIT

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21
Q

Vinblastine (Velban)

IV

A

breast, testicular, HN, lymphoma
Plant Alkaloid (cell cycle specific)
SE: mucositis, stomatitis, severe constipation, jaw pain
AVOID: SJ WORT, GRAPEFRUIT

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22
Q

TORISEL

oral

A

advanced renal cell
mTOR inhibitor
SE: hyperglycemia, elevated cholestrol

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23
Q

Tamoxifen (nolvadex)

oral

A
Breast
Anti Estrogen
SE: hot flashes, N/V/wt gain
AVOID: SJ WORK AND GRAPEFRUIT
Take calcium and vit d
24
Q

Nexavar

oral

A
liver, kidney
protein targeted tx, tyrosine kinase inhibitor
SE: n/v/d/a, hand-foot sx, white hair
TAKE ON EMPTY STOMACH 
AVOID SJ WORT
25
Q

Streptozocin(Zanosar)

IV

A

pancreas, carcinoid
Alkylating Agent, Vesicant
SE: HYPOGLYCEMIA, N/V

26
Q

PROVENGE (Sipuleucel T)

IV

A
metastatic prostate
Autologous cellular immunotherapy
SE: CHILLS
AVOID CAFFEINE 
TAKE WITH CALCIUM
27
Q

Stivarga (regorafenib)

Oral

A

colon
SE: n/v/d/a/mucositis
TAKE WITH A LOW FAT MEAL

28
Q

Matulane (procarbazine hydrochloride)

oral

A

hodgkins, NHL, brain tumors
Alkylating agent
SE: CONSTIPATION, dry mouth
FOLLOW A LOW TYRAMINE DIET, NO GINSENG

29
Q

Alimta (premetrexed)

injection

A

lung, mesothelioma
SE: n/v/d/f/severe anemia
GIVE FOLIC ACID AND B12

30
Q
5 FU (flouracil)
IV
A
breast, colon, GI, HN, pancreas, ovarian
Antimetabolite(cell cycle specific)
SE: n/v/d/mucositis
GIVE B6 TO AVOID HAND/FOOT SX
Have patients hold ice chips in the mouth to 15 minutes pre-and post IV to reduce incidence of oral mucositis
31
Q

mercaptopurine (6-MP)

oral

A

leukemias, lymphomas
Antimetabolite (cell cycle specific)
SE: n/v/d/mucositis, hyper uricemia, liver toxicity
AVOID DAIRY/ TAKE ON EMPTY STOMACH

32
Q

Velcade (bortezomib)

iv

A

multiple myeloma
Protease inhibitor
NO GREEN TEA

33
Q

Targretin (bexarotene)

oral

A

T cell lymphoma(myocosis fungoids)
NO GRAPEFRUIT
LIMIT VITAMIN A TO <= 150mg/day

34
Q

Bulsulfan (myleran

oral

A

CML
alkylating agent
SE: n/v/d, mucositis
AVOID ASPIRIN

35
Q

Alkeran (Mephalan)

oral

A

multiple myeloma, ovarian, breast, neuroblastoma
Alkylating agent
SE: n/v/d, mucositis
TAKE ON EMPTY STOMACH

36
Q

Leukeran (chlorambucil)

oral

A

pancreatic, CLL, lymphomas, breast, ovarian, testicular
SE: n/v/hyperuricemia
TAKE ON EMPTY STOMACH

37
Q

Methotrexate

pill or injection

A

ALL, breast, lung, NHL, HN, bladder, osteosarcoma
SE: n/mucositis, light sensitive
AVOID FOLIC ACID AND ETOH
TAKE ON EMPTY STOMACH

38
Q

Oxaliplatin (eloxatin)

IV

A

colon, pancreatic, GI
alkylating agent
SE: n/v/d, SENSITIVE TO COLD
B6 MAY DECREASE SEVERITY OF HAND/FOOT SX

39
Q

Cisplatin (platinol)

IV

A

cervical, esophageal, lung, HN, ovarian, prostate, testicular
alkylating agent
SE: METALLIC TASTE, KIDNEY TOXICITY, HEARING LOSS n/v/low magnesium, low appetite
HYDRATION IS IMPORTANT

40
Q

XELODA (capecitabine)

oral

A

colon, metastatic breast
SE: n/v/d, hand foot sx,
GIVE B6 (50-100mg)TO REDUCE HAND FOOT SX
TAKE WITHIN 30 MINUTES OF MEAL

41
Q

Sprycel

oral

A

CML, ALL

AVOID SJ WORT, GRAPEFRUIT

42
Q

Tarceva (erlotinib)

oral

A

NSCLC, metastatic pancreatic
protein targeted tx: tyrosine kinase inhibitor
SE: n/v/d/a, rash, hand foot sx
NO GRAPEFRUIT OR ST WORT

43
Q

Tykerb (lapatinib)

oral

A
HER 2+ met. breast
Targeted tx: tyrosine kinase inhibitor
SE: low, d/n/v/anemia
NO GRAPEFRUIT
TAKE ON EMPTY STOMACH
44
Q

Afinitor (everolimus)

oral

A

breast, renal, neuroendocrine
mTor kinase inhibitor
AVOID SJ WORT AND GRAPEFRUIT

45
Q

Exjade

oral

A

Oral IRON chelator
contains lactose
SE: diarrhea

46
Q

Tasigna

oral

A
CML
protein tyrokinase inhibitor
NO GRAPEFRUIT
TAKE ON EMPTY STOMACH
CONTAINS LACTOSE
47
Q

Gleevec

oral

A

CML, GIST
SE: rash, hand-foot sx, n/v/d, decreased appetite can turn hair white
AVOID SJ WORT AND GRAPEFRUIT

48
Q

Temodar

oral

A
glioblastoma
alkylating agent
SE: N/V, fatigue, headache, photosensitivity, rash
DO NOT CHEW OR CRUSH
TAKE ON EMPTY STOMACH
49
Q

Selective Estrogen Receptor Modulators

oral

A

Tamoxifen
Evista
Anti-Estrogens
SE: hot flashes, n/v, wt gain

50
Q

low tyramine diet

A
AVOID: 
alcohol
caffeine
raspberries
figs
dried fruit
avocado
banana
miso
soy sauce
kraut
aged cheese
anchovies
liver
sausage
bologna
pepperoni
51
Q

Arimidex

A

Increased risk of osteoporosis

52
Q

Beta Carotene

A

when taken in high doses may increase risk of lung cancer

53
Q

odynophagia

A

painful swallowing

54
Q

FASS

A

Fat
Acid
Salt
Sweet

55
Q

Eribitux

A

Monitor magnesium and calcium levels closely especially in elderly