Chemo Drugs Flashcards
Vidaza
IV
For bone marrow and blood cancers Antimetabolite Route: IV Side Effects: decreased vitamin K levels n/v/d/f
Vectibix
IV
For metastatic colon cancer
Monoclonal EGFR sensitive
Side Effect: D/low magnesium
Sutent
(oral)
GIST, renal pancreatic, neuroendrocrine
Protein Targeted therapy
SE: n/v/d/decreased appetite, hand-foot sx, rash, can turn hair white
NO GRAPEFRUIT
Epirubin (Ellence)
IV
Breast
Antitumor ATB- Cell Cycle Specific
SE: N/V/D/mucositis/rash
Gemzar
IV
Pancreatic/bladder/breast/ovarian/lung
Antimetabolite-Cell Cycle Specific (pyrimide antagonist)
SE: n/v/pulmonary/flu like sx/clay colored stools
Cytoxan (cyclophosphamide)
IV
Breast, ovarian, CLL, lymphomas Alkylating Agent (non cell cycle specific) SE: BLADDER TOXICITY, N/v PUSH FLUIDS Give Mensa to prevent bleeding cysts Can increase effect of anticoagulants
Taxol (paclitaxel)
IV
bladder, breast, ovarian, H&N, Esophageal, lung, prostate pancreatic Plant Alkaloid(taxane) SE: diarrhea/Mucositis
Doxil (doxorubin liposomal)
IV
Metastatic ovarian, Kaposi’s, breast
Antitumor ATB
SE: n/v/d/mucositis, hand foot sx
turns urine red
Adriamycin(doxorubin)
IV
breast, gastric, HN, lung, liver, kidney ALL and many more
Anthracycline ATB
SE: n/v/d/mucositis/hand foot sx, anorexia, “red devil”
Give Omega 3s/CoQ 10/Theanine- may reduce toxicity
Vinorelbine(navelbine)
IV
breast, ovarian, lung
Plant alkaloid
SE: constipation, stomatitis
a/n/v
Etoposide
IV
lung, gastric, testicular, bladder prostate
Plant Alkaloid (cell cycle specific)
SE: Metallic taste, a/n/v/d
Herceptin (Trastuzumab)
IV
metastatic breast cancer HER2/NEU
Monoclonol ATB
SE: n/v/d
avocados, olive oil increase sensitivity to drug
xgeva (denosumab)
injection
To prevent skeletal related events
Monocolonal ATB RANK inhibitor
SE: n/v/d, decreased Calcium
Osteonecrosis of jaw
Carboplatin (paraplatin)
IV
HN, bladder, ovarian, lung endo
Alkylating agent
SE: n/v, peripheral neuropathy
Treanda (bendamustine)
IV
CLL, NHL
Alkylating agent
SE: n/v/f
Tumor lysis syndrome
Iressa
oral
NSCLC
Protein target tx- tyrosine kinase inhibitor EGFR
SE: n/v/d, decrease appetite, hand-foot sx
Take with WATER
Kadcyla
IV
HER2+ metastatic breast
Monoclonal ATB
SE: Constipation, increased liver enzymes, n/f
List 3 Aromatase Inhibitors
Anastrozenole (Arimidex)
Aromasin(exemestane)
Femara
SE: hot flashes, fatigue, joint pain, blood clots, muscle aches, elev. chol, BONE LOSS
AntiEstrogens
Counsel to promote bone strength (calcium, vit D, exercise)
Zometa
IV
bone mets
Need 500 mg Calcium and 400 IU Vit D daily
Vincristine (oncovin)
IV
leukemia, lymphoma, Multiple Myeloma, brain
Plant Alkaloid (cell cycle specific)
SE: SEVERE CONSTIPATION, Jaw pain, decreased appetite
AVOID: SJ WORT, GRAPEFRUIT
Vinblastine (Velban)
IV
breast, testicular, HN, lymphoma
Plant Alkaloid (cell cycle specific)
SE: mucositis, stomatitis, severe constipation, jaw pain
AVOID: SJ WORT, GRAPEFRUIT
TORISEL
oral
advanced renal cell
mTOR inhibitor
SE: hyperglycemia, elevated cholestrol
Tamoxifen (nolvadex)
oral
Breast Anti Estrogen SE: hot flashes, N/V/wt gain AVOID: SJ WORK AND GRAPEFRUIT Take calcium and vit d
Nexavar
oral
liver, kidney protein targeted tx, tyrosine kinase inhibitor SE: n/v/d/a, hand-foot sx, white hair TAKE ON EMPTY STOMACH AVOID SJ WORT
Streptozocin(Zanosar)
IV
pancreas, carcinoid
Alkylating Agent, Vesicant
SE: HYPOGLYCEMIA, N/V
PROVENGE (Sipuleucel T)
IV
metastatic prostate Autologous cellular immunotherapy SE: CHILLS AVOID CAFFEINE TAKE WITH CALCIUM
Stivarga (regorafenib)
Oral
colon
SE: n/v/d/a/mucositis
TAKE WITH A LOW FAT MEAL
Matulane (procarbazine hydrochloride)
oral
hodgkins, NHL, brain tumors
Alkylating agent
SE: CONSTIPATION, dry mouth
FOLLOW A LOW TYRAMINE DIET, NO GINSENG
Alimta (premetrexed)
injection
lung, mesothelioma
SE: n/v/d/f/severe anemia
GIVE FOLIC ACID AND B12
5 FU (flouracil) IV
breast, colon, GI, HN, pancreas, ovarian Antimetabolite(cell cycle specific) SE: n/v/d/mucositis GIVE B6 TO AVOID HAND/FOOT SX Have patients hold ice chips in the mouth to 15 minutes pre-and post IV to reduce incidence of oral mucositis
mercaptopurine (6-MP)
oral
leukemias, lymphomas
Antimetabolite (cell cycle specific)
SE: n/v/d/mucositis, hyper uricemia, liver toxicity
AVOID DAIRY/ TAKE ON EMPTY STOMACH
Velcade (bortezomib)
iv
multiple myeloma
Protease inhibitor
NO GREEN TEA
Targretin (bexarotene)
oral
T cell lymphoma(myocosis fungoids)
NO GRAPEFRUIT
LIMIT VITAMIN A TO <= 150mg/day
Bulsulfan (myleran
oral
CML
alkylating agent
SE: n/v/d, mucositis
AVOID ASPIRIN
Alkeran (Mephalan)
oral
multiple myeloma, ovarian, breast, neuroblastoma
Alkylating agent
SE: n/v/d, mucositis
TAKE ON EMPTY STOMACH
Leukeran (chlorambucil)
oral
pancreatic, CLL, lymphomas, breast, ovarian, testicular
SE: n/v/hyperuricemia
TAKE ON EMPTY STOMACH
Methotrexate
pill or injection
ALL, breast, lung, NHL, HN, bladder, osteosarcoma
SE: n/mucositis, light sensitive
AVOID FOLIC ACID AND ETOH
TAKE ON EMPTY STOMACH
Oxaliplatin (eloxatin)
IV
colon, pancreatic, GI
alkylating agent
SE: n/v/d, SENSITIVE TO COLD
B6 MAY DECREASE SEVERITY OF HAND/FOOT SX
Cisplatin (platinol)
IV
cervical, esophageal, lung, HN, ovarian, prostate, testicular
alkylating agent
SE: METALLIC TASTE, KIDNEY TOXICITY, HEARING LOSS n/v/low magnesium, low appetite
HYDRATION IS IMPORTANT
XELODA (capecitabine)
oral
colon, metastatic breast
SE: n/v/d, hand foot sx,
GIVE B6 (50-100mg)TO REDUCE HAND FOOT SX
TAKE WITHIN 30 MINUTES OF MEAL
Sprycel
oral
CML, ALL
AVOID SJ WORT, GRAPEFRUIT
Tarceva (erlotinib)
oral
NSCLC, metastatic pancreatic
protein targeted tx: tyrosine kinase inhibitor
SE: n/v/d/a, rash, hand foot sx
NO GRAPEFRUIT OR ST WORT
Tykerb (lapatinib)
oral
HER 2+ met. breast Targeted tx: tyrosine kinase inhibitor SE: low, d/n/v/anemia NO GRAPEFRUIT TAKE ON EMPTY STOMACH
Afinitor (everolimus)
oral
breast, renal, neuroendocrine
mTor kinase inhibitor
AVOID SJ WORT AND GRAPEFRUIT
Exjade
oral
Oral IRON chelator
contains lactose
SE: diarrhea
Tasigna
oral
CML protein tyrokinase inhibitor NO GRAPEFRUIT TAKE ON EMPTY STOMACH CONTAINS LACTOSE
Gleevec
oral
CML, GIST
SE: rash, hand-foot sx, n/v/d, decreased appetite can turn hair white
AVOID SJ WORT AND GRAPEFRUIT
Temodar
oral
glioblastoma alkylating agent SE: N/V, fatigue, headache, photosensitivity, rash DO NOT CHEW OR CRUSH TAKE ON EMPTY STOMACH
Selective Estrogen Receptor Modulators
oral
Tamoxifen
Evista
Anti-Estrogens
SE: hot flashes, n/v, wt gain
low tyramine diet
AVOID: alcohol caffeine raspberries figs dried fruit avocado banana miso soy sauce kraut aged cheese anchovies liver sausage bologna pepperoni
Arimidex
Increased risk of osteoporosis
Beta Carotene
when taken in high doses may increase risk of lung cancer
odynophagia
painful swallowing
FASS
Fat
Acid
Salt
Sweet
Eribitux
Monitor magnesium and calcium levels closely especially in elderly
