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Chemotherapy > Chemo Drugs > Flashcards

Chemo Drugs Flashcards

Mechanism and side effects

1
Q

Cyclophosphamide: Mechanism

A

Alkylating agent (cross linking in DNA)

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2
Q

Cyclophosphamide: SE

A

Haemorrhagic cystits, myelosupression and transitional cell carcinoma

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3
Q

Bleomycin: Class and Mechanism

A

Cytotoxic ABX; degrades DNA

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4
Q

Bleomycin: SE

A

Lung fibrosis

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5
Q

Doxorubicin: Class and Mechanism

A

Cytotoxic ABX: Stabilises the DNA:topiosomerase complex therefore inhibits DNA/RNA synth

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6
Q

Doxorubicin: SE

A

Cardiomyopathy

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7
Q

Methotrexate: Class and Mechanism

A

Antimetabolite: inhibits dihydrofolate reductase and thymidylate synth

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8
Q

Methotrexate: SE

A

Myelosupression, mucositis, lung and liver fibrosis

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9
Q

5-FU: Class and Mechanism

A

Antimetabolite: cell cycle arrest and apoptosis

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10
Q

5-FU: SE

A

Myelosupression, mucositis and dermatitis

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11
Q

Cytarabine: Class and Mechanism

A

Antimetabolite: pyrimidine antagonist (inhibits DNA synth)

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12
Q

Cytarabine: SE

A

Myelosupression, ataxia

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13
Q

Vincristine and Vinblastine: Mechanism

A

Act on microtubules

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14
Q

Vincristine: SE

A

Peripheral neuropathy, paralytic ileus

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15
Q

Vinblastine: SE

A

Myelosupression

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16
Q

Docetaxel: Mechanism

A

Acts on microtubules

17
Q

Docetaxel: SE

A

Neutropenia

18
Q

Cisplatin: Mechanism

A

Causes cross-linking in DNA

19
Q

Cisplatin: SE

A

Ototoxicity, peripheral neuropathy, hypoMg

20
Q

Hydroxyurea: Mechanism

A

Reduces DNA synth

21
Q

Hydroxyurea: SE

A

Myelosuppression

Chemotherapy (1 decks)

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