Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

BCP > Chemo Drugs > Flashcards

Chemo Drugs Flashcards

1
Q

Antimetabolites

A

Drugs: Methotrexate, Fluorouracil

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Methotrexate

A

An antimetabolite (Compete with purine or pyrimidine analogs by getting incorporated into RNA/DNA inhibiting synthesis, targets S phase of cell cycle)

Folate antagonist

Indications: ALL, breast ca, head and neck ca, non-Hodgkin’s lymphoma, osteosarcoma

Adverse Effects: Acute N,V, mucositis,
Delayed: myelosuppression, nephrotoxicity, hepatotoxicity, photosensitivity, pulmonary toxicity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

fluorouracil (pyrimidine analog)

A

Indications: Breast, colon and gastric CA

Adverse Effects - Acute: N/V/D
Delayed: Stomatitis, GI ulcer, hand-foot syndrome, cardiotoxicity, photosensitivity, myelosuppresion

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

topoisomerase inhibitors

A

Etoposide, Irinotecan

MOA: Binds topo I and stabilizes cleavable complex, so relegation of cleaved DNA strand cannot occur. Leads to DNA strand break. Targets S phase of cell cycle.

Indications: small cell lung ca, NHL

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Etoposide

A

topoisomerase inhibitors

Indications: small cell lung ca, NHL

Adverse Effects: Acute: N/V/D, hypersensitivity, fever, hypotension Delayed: myelosuppression, alopecia, fatigue
inflamed mucous membranes, secondary malignancies, hepatoxicity (from lecture)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

irinotecan

A

topoisomerase inhibitors

Indications: small cell lung ca, NHL

Adverse Effects: Acute:N/V/D cholinergic syndrome,
Delayed: myelosuppression, alopecia, asthenia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

anthracyclines (topoisomerease II inhibitor)

A

doxorubicin

MOA: Binds to topo II and causes DNA strand breaks, targets S/G2 phase of cell cycle

Indications: breast ca, metastatic solid tumors, leukemia, lymphoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

doxorubicin

A

Anthracycline (topoisomerease II inhibitor)

MOA: Binds to topo II and causes DNA strand breaks, targets S/G2 phase of cell cycle

Indications: breast ca, metastatic solid tumors, leukemia, lymphoma

Adverse Effects: cardiotoxicity, extravasation potential, secondary malignancies, hepatic function impairement, myelosupression

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

antimicrotubules - taxanes

A

MOA: Promotes formation of microtubules and prevents disassembly of microtubules, targets G2/M phase

Drug: Paclitaxel

Indications: ALL, CNS tumors, Hodgkin lymphoma, NHL

Adverse Effects: Acute: N/V/D, hypersensitivity
Delayed: peripheral neuropathy, alopecia, mucositis, arthralgias

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

vinca alkyloids

A

MOA: Binds to tubulin and inhibits microtubule assembly, targets M phase

Drug: Vincristine

Indications: ALL, CNS tumors, Hodgkin lymphoma, NHL

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Paclitaxel

A

Class: antimicrotubules - taxanes

MOA: Promotes formation of microtubules and prevents disassembly of microtubules, targets G2/M phase

Indications: ALL, CNS tumors, Hodgkin lymphoma, NHL

Adverse Effects: Acute: N/V/D, hypersensitivity
Delayed: peripheral neuropathy, alopecia, mucositis, arthralgias

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Vincristine

A

Class: vinca alkyloids

MOA: Binds to tubulin and inhibits microtubule assembly, targets M phase

Indications: ALL, CNS tumors, Hodgkin lymphoma, NHL

Adverse Effects: Acute: constipation, nausea
Delayed: fatigue neurotoxicity, cranial nerve disorder

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

alkylating agents

A

Drugs: cyclophosphamide, cisplatin

Indications: breast ca, lymphomas, leukemias (cyclophosphamide), solid tumors (cisplatin)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

cyclophosphamide

A

Class: alkylating agents

Indications: breast ca, lymphomas, leukemias

Adverse Effects: Acute: N/V
Delayed: hemorrhagic cystitis, cardiotoxicity, alopecia, myelosuppression

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

cisplatin

A

Class: alkylating agents

Indication: solid tumors

Adverse Effects: Acute: N/V
Delayed: renal toxicity, ototoxicity,neurotoxicity, myelosuppression, electrolyte disturbances

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

hormonal agents:

hormone therapies

A

Drugs: tamoxifen, leuprolide

Indications: breast cancer (tamoxifen), breast cancer, 
prostate cancer (leuprolide)
17
Q

tamoxifen

A

hormone therapy

Indications: breast cancer

Adverse Effects: Acute: none
Delayed: hot flashes, vaginal discharges, menstrual irregularities, arthralgias

18
Q

leuprolide

A

Class: hormone therapy

Indications: breast cancer,
prostate cancer

Adverse Effects: Acute: infection site discomfort
Delayed: hot flashes, tumor flare, edema, decreased libido, erectile dysfunction, osteoporosis

19
Q

targeted therapies

tyrosine kinase inhibitors

A

Drug: imatinib

Indications: CML, GIST (gastrointestinal)

20
Q

imatinib

A

Class: tyrosine kinase inhibitors

Indications: CML, GIST (gastrointestinal)

Adverse Effects: Acute: nausea, vomiting, diarrhea
Delayed: edema, muscle cramps, rash, myelosuppression, hepatotoxicity

21
Q

monoclonal antibodies

A

Drug: bevacizumab

22
Q

bevacizumab

A

Class: monoclonal antibodies

Indications: colon cancer, cervical, glioblastoma, non-small cell lung cancer, ovarian, renal CA.

AE: Acute: infusion-related reaction
Delayed: hypertension, proteinuria, wound healing complications, GI perforation, hemorrhage

BCP (3 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions