Chemo Drug Toxicities

Question 1

myelosuppresion

Answer 1

most; few that don’t= bleomycin, vincristine, most mAbs

Question 2

neuropathy

Answer 2

platinums, taxanes, vincas

Question 3

cardiotoxicity

Answer 3

anthracyclines, TKIs, breast CA drugs

Question 4

pulmonary toxicity

Answer 4

alkylators, bleomycin, MTX

Question 5

nephrotoxicity/bladder toxicity

Answer 5

bevacizumab, MTX, platinums (amifostine (Ethyol) for cisplatin), cyclophosphamide/ifosfamide (mesna (Mesnex))

Question 6

acneiform rash

Answer 6

cetuximab, erlotinib, etc

Question 7

mucositis

Answer 7

5-FU, capecitabine, irinotecan, MTX

Question 8

hand-foot syndrome

Answer 8

capecitabine, cytarabine, 5-FU, liposomal doxorubicin

Question 9

hepatotoxicity

Answer 9

antiandrogens, antimetabolites, aromatase inhibitors, SERMs, vincas, some TKIs

Question 10

clotting risk

Answer 10

SERMs, bevacizumab, -domides

Question 11

alopecia

Answer 11

100%= taxanes, anthracyclines; others= carboplatin, cyclophosphamide, ifosfamide, etoposide, vincas

Question 12

extravasation

Answer 12

cold compress for all except vincas and etoposide (use warm); hyaluronidase for vincas; dexrazoxane for anthracyclines