Chemo

Question 1

Chemotherapeutic drugs may also be called

Answer 1

antineoplastic drugs

Question 2

Chemo drugs work on cells that are:

Answer 2

actively undergoing mitosis or DNA synthesis

Question 3

Chemo is usually done with several drugs and is

Answer 3

planned according to cell division

Question 4

limiting factor in chemo treatment

Answer 4

myelosuppression

Question 5

Alykylating agents are aimed at what phase of cell cycle?

Answer 5

nonspecific

Question 6

Antitumor antibiotics are aimed at what phase of cell cycle?

Answer 6

G1 and S

Question 7

Antimetabolites are aimed at what phase of cell cycle?

Answer 7

S

Question 8

Taxoids/Taxanes are aimed at what phase of cell cycle?

Answer 8

G2 and M

Question 9

Vinca alkaloids are aimed at what phase of the cell cycle?

Answer 9

M and G1

Question 10

Alkylating agents MOA:

Answer 10

impair cell function by forming covalent bonds in proteins, DNA, and RNA

Question 11

Antimetabolites MOA:

Answer 11

substitute for metabolite in DNA or RNA or compete for catalytic site of key enzyme

Question 12

Antitumor antibiotics MOA:

Answer 12

create free radicals

Question 13

Topoisomerase inhibitors:

Answer 13

uncoil DNA during replication

Question 14

Tubulin-binding (Vinca alkaloids and taxoids) drugs MOA:

Answer 14

vinca: bind to tubular and prevent formation of microtubule
taxoids: prevent disassembly microtubules

Question 15

Signal transduction modifiers MOA:

Answer 15

disruption of normal growth factor receptor interactions

Question 16

Alkylating agents, list drug classes:

Answer 16

Nitrogen Mustards
Alkyl sulfonates
Nitrosoureas
Triazenes

Question 17

Resistance in common in which agents?

Answer 17

Alkylating agents

Question 18

Nitrogen Mustards (list of drugs)

Answer 18

Mechlorethamine
Cyclophosphamide
Chlorambucil
Mephalan

Question 19

SE of all nitrogen mustards

Answer 19

herpes zoster

thrombophlebitis

Question 20

Bisulfan class

Answer 20

Alkyl sulfonates

Question 21

SE Bisulfan

Answer 21

Pulmonary fibrosis

Question 22

Mitomycin class

Answer 22

Nitrosoureas

Question 23

Mitomycins SE

Answer 23

pulmonary fibrosis
leukopenia
thrombocytopenia
N/V/alopecia

Question 24

Mitomycin use:

Answer 24

palliative treatment gastric adenocarcinoma

Question 25

Prevention of pulmonary fibrosis in bleomycin and mitomycin:

Answer 25

limiting O2 (avoid hyperoxemia)

Question 26

Limiting factor cisplatin:

Answer 26

renal toxicity, given with diuretic and fluid to try to prevent this

Question 27

Topoisomerase Inhibitors (drugs)

Answer 27

Doxorubicin
Daunorubicin
Dactinomycin
Bleomycin

Question 28

Doxorubicin and Daunorubicin big SE

Answer 28

cardiomyopathy (more so Doxorubicin)

Question 29

Cardiomyopathy in Doxorubicin, what do you look for?

Answer 29

pre chemo and post chemo echo

EKG changes: SVT, PVCs, decreased QRS voltage

Question 30

Bleomycin

Answer 30

Pulmonary toxicity in 4% patients
FiO2 <30%, SpO2 >90%
decrease fluids

Question 31

Tubulin Binding Drugs include which two groups?

Answer 31

Vinca Alkaloids and Taxanes

Question 32

Taxanes big SE:

Answer 32

Severe neurotoxicity

Question 33

Vinca Alkaloid SE:

Answer 33

10% pts autonomic neuropathy, orthostatic hypotension, bowel dysfunction
Cranial nerves involved
Laryngeal nerve paralysis w/ hoarseness, weakness of extraocular muscles