Chemo

Question 1

Growth Factor Receptor Inhibitors

Answer 1

Mabs and Nibs - OVERLAP W TYROSINE KINASE INHIBS

Cetuxumab
Bevacivumab

Lapatinib
Pazopanib
Sorafenib

Question 2

Growth Factor Receptor Inhibitors (Nibs and Mabs)- ADRs

Answer 2

GERD
Diarrhea

Back Pain
Mouth Ulcers

Question 3

Vinca Alkaloids

Answer 3

Vinblastine

Vinorelbine

Question 4

Vinca Alkaloid (Vinblast, Vinor) ADRs !!

Answer 4

Low Blood Counts Frequent CBCs **

Poor Appetite
Mouth Sores
N/V/D

Question 5

Epipodophyllotoxins

Answer 5

Etoposide

Teniposide

Question 6

Epipodophyllotoxins (Etoposide, Teniposide) ADRs

Answer 6

Thrombocytopenia
Leukopenia

Hypotension

N/V/D
Anorexia

Question 7

Tyrosine Kinase Inhibitors

Answer 7

NIBS AND MABS - OVERLAP W GROWTH FACTOR INHIBS

Imatinib

Cardiac and Pulmonary Toxicity

Question 8

Anthracyclines !!

Answer 8

Doxorubicin (etc, other -rubicins)

Mitoxanthrone

Question 9

Anthracycline (Doxorubicin) ADRs

Answer 9

CARDIOTOXICITY

Myelosuppression

(need Echo, EKB, CBC, LFT)

Question 10

Platinum Analogs

Answer 10

Carboplatin

Question 11

Platinum Analog (Carboplatin) ADRs

Answer 11

Renal and Hepatic

Myelosuppression

Question 12

Camptothecins

Answer 12

Topotecans

Irinotecans

Carboplatin

Question 13

Camptothecins (Topotecan, Irinotecan, Carboplatin) ADRs

Answer 13

Anemia
Neutropenia
Thrombocytopenia

Question 14

Antimetabolites !!!

Answer 14

METHOTREXATE
5FU
Deoxycytidine

Question 15

Antimetabolite (Methotrexate, 5FU, Deoxycytidine) ADRs

Answer 15

MTX Black Box!!&raquo_space; BM, liver, kidney, lung toxicity. Death.

5FU: NEUROTOXICITY

Question 16

1st gen Antiemetics (CINV 5HT3)

Answer 16

Zofran

Blocks serotonin receptors peripherally, in gut

Question 17

2nd gen Antiemetic

Answer 17

Aloxi

acute and delayed N/V b/c of prolonged half-life - do not take w/in 3 days of taking Ondansetron [Zofran]!