Chemistry Viva Flashcards
Gastric fluid
Secretions of digestive enzymes, mucus and hydrochloric acid
Necessity of acid
Dissolving minerals and destroy bacteria that may enter the stomach with food
Enables inactive forms of digestive enzymes to be converted to active (pepsinogen -> pepsin)
Symptoms of hyperacidity
Heartburn, stomach ulcers
Details of HCL solution used in experiment
0.1 M, 0.4-0.5% by mass
Systematic/absorbable antacids
Soluble
Readily absorbable
Capable of producing systemic electrolyte disturbances
Sodium bicarbonate
Non-systemic/non-absorbable
Not absorbed and act exclusively in the GIT
Calcium carbonate
Aluminium hydroxide
Magnesium carbonate
Complex antacids
Magaldrate
Almagate
Hydrotalcite
Side effects of antacids
Constipation
Flatulence
Headache
Nausea
Vomiting
Stomach cramps
Pain in the abdomen
Serious side-effects
Acid rebound
Neuro toxicity
Microcytic anaemia
Osteopenia
Hypercalcaemia
Mechanism of action of antacids
Buffer the stomach acid, increase pH
CNS is alerted to pain when gastric HCL reaches the nerves in the gastrointestinal mucosa (peptic ulcers)
Outline of project
Standardisation of HCL solution in burette
Phenolphthalein indicator
Compared digene Zantac, pentacid
Order of strength Zantac > dig > P acid
Precautions during project
Bureau cleared and well clean from impurities, ensure no bubbles
Shaikh flask after every step
Rinse pipette with solution to be used
