Chemistry and Physiology Flashcards
1
Q
Membrane components
A
phospholipid bilayer, pores and proteins
2
Q
What is the most important active transport system?
A
P-glycoproteins
3
Q
T/F: smaller size easily crosses membrane
A
True
4
Q
What solution do hydrosoluble drugs diffuse better in?
A
hydrosoluble - like water
5
Q
Are hydrosoluble particles charged?
A
yes
6
Q
T/F: ionized particles have lower hydrosolubility
A
False - higher
7
Q
What is the ionization constant K?
A
value of equilibrium between ionized and non-ionized
8
Q
What is ion trapping?
A
weak acid in basic fluid
weak base in acidic fluid
9
Q
What is chelation?
A
binding to metal ions
10
Q
What is hydrolysis?
A
splitting molecules by adding water
11
Q
What is oxido-reduction?
A
loss or gain of electron
12
Q
What is tautomerization?
A
conversion between isomeres
