Chemistry Flashcards

1
Q

Conjugate acid

Conjugate base

A

The acid on the product side.

The base on the product side

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2
Q

Strong acid

Weak acid

A

Large Ka, Small pKa

Small Ka, Large pKa

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3
Q

Strong base

Weak base

A

Small Ka, Large pKa

Large Ka, Small pKa

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4
Q

How to work out conc of strong acid?

A

pH=-log10 [H30+]

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5
Q

How to work out conc of strong base?

A

Kw=[H30+] [OH-]

kw=10 -14

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6
Q

How to work out conc of weak acid?

A

pH=0.5pKa-0.5log[HA]

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7
Q

How to work out conc of weak base?

A

pH=0.5pKw+0.5pKA+0.5log [B]

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8
Q

Henderson Hasselbalch acid

A

pH=pKa+log [Base]/[Acid]

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9
Q

Henderson Hasselbalch base

A

pH=pKa+log [B]/[BH+]

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10
Q

Blood buffer system

A
  • Acid produced by body
  • Reacts with bicarbonate (HCO3-)
  • Produces carbonic acid (H2CO3)
  • Carbonic acid dissociates to give CO2 + H2O

H2CO3 –> H+ + HCO3-
H2CO3 –> H20 + CO2

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11
Q

pKa equation

A

pKa=-log10 Ka

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12
Q

Raft forming agents

A

Alginic acid: If pH falls below 3.5, precipitate appears as a gel which swells and absorbs=raft formed
Bicarbonate: CO2 trapped and helps raft float
Calcium cations: Interact with alginate and aid crosslinking, increase raft viscosity.

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13
Q

Antifoaming agents

A

Simeticone

  • Silicone polymer
  • Lowers surface tension of gas bubbles
  • Relieves trapped wind
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14
Q

Antacids

A

Act locally
Maintain pH 3-6
Fast acting and long duration

Calcium carbonate

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15
Q

Bond Energies (Acid)

A

Weaker bond=Better acid

Can lose proton easier

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16
Q

Electronegativity (Acid)

A

More electronegative=better acid

Pulls electrons towards centre, easier for H to leave

17
Q

Inductive effect (Acid)

A

Electron withdrawing=Better acid

Electron donating=Worse acid

18
Q

Resonance (Acid)

A

If conjugate base has more resonance.
A- more stable
Better acid

19
Q

PPI’s

A

Omeprazole
Weak base
Pro drug
When pH=pKa-Ionisation is 50/50