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I&D Week 4 > Chemical Mediators and Responses > Flashcards

Chemical Mediators and Responses Flashcards

1
Q

IL1

A

Inflammation, increase expression of adhesion in endothelial cells, fever, IL6 production

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2
Q

IL2

A

Proliferation & differentiation of T cells (promotes regulatory T cells in Thymus, and also memory T cells and effector T cells)

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3
Q

IL3

A

Maturation of hematopoietic lineages, macrophage differentiation; secreted by basophils and activated T-cells

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4
Q

IL4

A

naïve T cell –> TH2 cell differentiation, B cell proliferation & differentiation, IgG1, IgE isotypes; secreted by TH2 cells (positive feedback loop)

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5
Q

IL5

A

Plasma cell differentiation, IgA isotype, eosinophil activation; secreted by TH2 cells and mast cells

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6
Q

IL6

A

Fever, acute phase response, plasma cell differentiation, Th17 differentiation; secreted by macrophages, endothelial cells and T-cells

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7
Q

IL7

A

proliferation of B & T cell progenitors, survival of naïve and Memory T cells; secreted by fibroblasts, bone marrow stroma cells

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8
Q

IL10

A

B-1 proliferation, inhibits macrophages

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9
Q

IL12

A

NK cell activation (IFN-y synthesis and increased cytotoxicity, TH1 differentiation; secreted by macrophages and dendritic cells

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10
Q

IL13

A

B cell differentiation, IgE isotype, macrophage alternate activation, increased mucus production in epithelial cells; secreted by Th2 cells, NKT cells, mast cells

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11
Q

IL15

A

Proliferation of memory CD8+ T cells and NK cells; secreted by macrophages

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12
Q

IL17

A

Increased cytokine and chemokine production by macrophages and endothelial cells; secreted by Th17 cells (basically, this is just a “stuff multiplier”)

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13
Q

TNFα

A

Inflammation, endothelial cell activation, neutrophil activation, fever, FDC differentiation, cachexia; secreted by T cells and B cells

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14
Q

TGFβ

A

Treg & Th17 differentiation, B cell differentiation, IgG2b, IgA, inhibits macrophages; secreted by Tregs, macrophages (this is the “turn off” cytokine)

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15
Q

IFNγ

A

Macrophage activation, TH1 differentiation, B cell differentiation, IgG2a, IgG3 isotypes; secreted by Th1, CD8+, and NK cells and group 1 ILCs (a general “turn on” cytokine”

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16
Q

IFNα

A

Inhibits viral replication, increases MHC Class I expression, activates NK cells; secreted by plasmacytoid dendritic cells, macrophages

17
Q

IFNβ

A

Inhibits viral replication, activates NK cells

18
Q

GCSF/MCSF/GMCSF

A

Granulocyte/monocyte differentiation, stem cell recruitment; secreted by macrophages, fibroblasts and endothelial cells (this is a “let’s think about starting” cytokine)

19
Q

Histamine

A

Vasodilation/vascular permeability, endothelial cell activation; secreted from granules of mast cells

20
Q

Prostacyclin

A

Vasodilation

21
Q

Thromboxane

A

Vasoconstriction

22
Q

Prostaglandin E2 (PGE2)

A

Pain, central nervous system mediator of fever; secreted by mast cells in allergic reactions, otherwise derived from arachidonic acid in many cell types

23
Q

Leukotrienes

A

Vascular permeability, bronchoconstriction; derived from arachidonic acid in many cell types, secreted by mast cells in bronchial asthma

24
Q

Lymphotoxin (LT)

A

FDC differentiation, activates endothelial cells and neutrophils; secreted by T cells

25
Q

Complement

A

Opsonization, chemotactic, membrane attack

26
Q

Bradykinin

A

Pain, endothelium-dependent vasodilation and permeability

27
Q

CXCL8 (IL8)

A

Major chemotactic factor of neutrophils

28
Q

CCL2 (MCP-1)

A

Macrophage recruitment to sites of inflammation

29
Q

CCL3 (MIP-1α)

A

T cell recruitment; major HIV-suppressive factor

30
Q

CCL5 (RANTES)

A

Monocyte, memory T and eosinophil recruitment

31
Q

CCL19 (MIP3β)

A

Naïve B & T cell recruitment to secondary lymphoid tissues

32
Q

CCL21 (SLC)

A

Naïve B & T cell recruitment to secondary lymphoid tissues

33
Q

CCL11 (Eotaxin)

A

Eosinophil recruitment

34
Q

CCL18

A

Naïve T cell recruitment by mature DC

35
Q

CCL25

A

Effector T cell recruitment to gut epithelium

36
Q

CXCL13

A

B cell recruitment to primary follicle

I&D Week 4 (4 decks)

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