Chemical Component of Cells Flashcards

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1
Q

What is an atom?

A

The smallest fundamental unit of matter

Everything comes from the atom. Atom are require to build elements, and elements are required to build organic compound such as water, fat, etc.

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2
Q

What makes an atom?

A
  1. Nucleus consist of protons and neutrons
  2. Electron surrounds the nucleus

The number of protons determine its atomic number and electron, meaning the number of protons determine the identity of the atom.

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3
Q

What is the differences between atomic number and atomic weight

A

Atomic Number: The number of proton an atom has

Atomic Weight: The number of proton and neutron an atom has in its nucleus

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4
Q

Types of Chemical Bonds

A

Strong Bonds: Covalent Bond and Ionic Bond

Weak Bonds: Hydrogen Bond, Hydrophilic Bond, Van der Waals

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5
Q

What is a covalent bond?

A

Electrons are shared between two elements.

For example: HCL
Both Chlorine and Hydrogen only needs one more electron to complete its outer shell. Therefore, they will share their last electron with each other to complete their outer shell.

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6
Q

What is an Ionic Bond?

A

Electrons are transferred from one atom to another.

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7
Q

Why is it better to transfer electrons in a ionic bond?

A

Electrons are transferred because it is more favorable for metal atoms to lose their electrons and nonmetals to gain electrons, rather than sharing the electrons.

Example: NaCl

It is better for Na to lose one electrons than to gain 7 electrons. Vice versa, it is better for Cl to gain one electron than to lose electrons. If Na, lose one electron, it will become stable because its outermost shell will be complete and if Cl gain one more electron, it will complete its outershell.

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8
Q

Why does chemical bond occur?

A

Atoms want to fill their incomplete shell because an incomplete shell is less stable than a complete shell. Therefore, atoms with incomplete outer shell tend to gain or lose electrons to fill their outer shell.

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9
Q

Describe the relationship between the number of chemical bond and how that affects bond strength.

A

Single bonds are longer but weaker than double and triple bond. More bond prevents rotation, producing a more rigid and less flexible arrangement of atoms. Moreover, the more bond a molecule has, the stronger its attractive force, causing the length to be shorter but stronger. Therefore, the stronger the bond, the more energy is needed to invest to break the bond.

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10
Q

Why is the strength of ionic bonds greatly affected by water but covalent bonds are not?

A

Water consist of dipole moments that are attracted to the cations and anions in an ionic bond. The partial negative dipole of oxygen is attracted to the cation and the partial positive dipole of hydrogen is attracted to the anion. This cause the salt to dissolve, causing a partially shield charge between ions, separating the salt (which dissolve the salt ).

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11
Q

What is a hydrogen bond?

A

An electrostatic attraction between a hydrogen atom in one polar molecule and a small electronegative attraction in another atom.

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12
Q

How does a hydrogen bond work?

A

In each water molecule, there is a slight positive charge on the hydrogen atom because its electron is being attracted by the oxygen atom, resulting a slightly negative charge on the oxygen atom. Therefore, the partial positive charge of the hydrogen is attracted to another slightly negative charge of another atom (usually the oxygen in another water molecule), forming a hydrogen bond.

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13
Q

What is a hydrophobic interaction?

A

The interaction between non-polar molecules and water that results in the attractions between multiple non-polar molecules.

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14
Q

How does Hydrophobic Interaction work?

A

Non-polar molecules are repelled in the presence of water molecule until it is attracted to other non-polar molecules to minimize polar contact in its environment.

Example: Fat mixing together in water
Fat molecules tend to clump together to minimize water contact.

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15
Q

What are the properties of water? What is responsible for water’s unique properties?

A
  1. Water is polar because of its asymmetrical charge distribution, uneven distribution of molecule from the oxygen. This produces dipole molecules.
    Many properties depend on water’s ability to make hydrogen bond

Unique properties of water

  • Liquid at room temperature; if the molecule were straight, the charges would cancel each other out, and water would be a gas.
  • High Boiling Point; bonding causes linkages in the water molecules which result in the boiling point of water is more than that of the other compounds.
  • High Specific Heat; The bonding between other water molecule contributes to water’s high specific heat.
  • Surface Tension; Due to water’s dipole moment, the partial charges of water cause a strong electrostatic attraction between other water molecule.
  • Lower Density as Solid; the orientation of hydrogen bonds causes molecules to push farther apart, lowering the density
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16
Q

What is an acid?

A

Any molecule capable of releasing (donating) a hydrogen ion (proton).

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17
Q

What are the characteristic of an acid?

A
  1. Acid affects pH by lowering the pH. The higher the concentration of hydrogen ion in a solution, the lower the pH.
  2. All acid have a conjugate base

Strong Acid: lose their proton easily
Weak Acid: holds on to their proton in the presence of water
-Weak Acids will give up their protons more readily if the H+ concentration is low (and the pH is high) and will hold onto their protons (or accept them back) when the H+ concentration
is high (and the pH is low).

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18
Q

What is a base?

A

Any molecule capable of accepting a hydrogen ion (proton).

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19
Q

What is the characteristic of a base?

A
  1. Raises the concentration of hydroxyl (OH–) ions by removing a proton from a water molecule. This cause pH to rise.
  2. All base have a conjugate acid.

Strong Base: Fully dissociate in water to form OH- ions.
Weak Base: Partially dissociate in water

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20
Q

What is a Buffer

A

A solution that consist of a mixture of weak acid and weak base that can resist pH change upon the addition of an acidic or basic components.

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21
Q

What is the application of buffer?

A

In a cell setting, a buffer keeps the pH of the cell relatively constant under a variety of conditions.
For enzymes, they depend on a buffer to prevent a rapid change in pH that may cause denaturalization.

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22
Q

What are the four major class of biological molecules?

A

sugar, fatty acid, amino acid, nucleotide

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23
Q

Sugar (Carbohydrate)

A

One of the four macromolecules of life made of carbon, hydrogen, oxygen
- General Formula: (CH2O)n
-

24
Q

Isomer

A

Two or more compounds with the same formula but a different arrangement of atoms
- This can cause the compound to have different roles

Example: Glucose, Mannose, Galactose

25
Q

Glycosidic Bond

A

Type of covalent bond that links monosaccharides together.

- This is how polysaccharides are joined together

26
Q

What is a condensation reaction?

A

A bond formed from the result of eliminating a water molecule.
- generally energetically unfavorable because more complex molecules are being built

27
Q

How does a condensation reaction work?

A

A water molecule is used to form the bond.

Example: Two glucose molecules
The H from the Carbon-1 on the first glucose and the OH from Carbon-4 in the second glucose come together to produce water. The water molecule is removed forming a glycosidic bond.

28
Q

What is glucose good for?

A
  • Energy Storage (glycogen)
  • Structure of Cells (cellulose)
  • Cell Communication (glycoprotein)
  • Blood Type
29
Q

What is the differences between the polysaccharide that makes starch and the polysaccharide that makes cellulose.

A

Starch are composed of alpha glucose monomers and cellulose are composed of beta glucose monomers.

For alpha glycosidic bond, the OH on the carbon-1 is below the glucose ring and stays below. For beta glycosidic bond, the OH on the carbon-1 is above the glucose ring, thus the bond will take a zig-zag shape.

30
Q

What are Fatty Acid

A

Long, unbranched hydrophobic hydrocarbon chains with single hydrophilic carboxyl group on the end

31
Q

What binds fat together? How does the binding work?

A

An Esther bond binds fat together. The hydroxyl from the glycerol join with the carboxyl’s hydroxyl’s hydrogen to release a water molecule, binding it. (Condensation Reaction )

32
Q

What does amphipathic mean? What makes fatty acid an amphipathic?

A

Amphipathic means to have both hydrophobic and hydrophilic parts. Fatty acids have a long hydrocarbon chain that are hydrophobic because hydrocarbons are non-polar. Fatty acids have a carboxyl head that is polar, making it hydrophilic.

33
Q

What are the functions of fats?

A

Establishment of lipid bilayer for phospholipids.

  • lipid are organized so that the polar head faces the water and the hydrophobic tail forms the core of the membrane. (Hydrophobic interaction)
  • Energy storage (triglyceride)
  • Function as a hormone (cholesterol)
  • Signaling molecule
34
Q

How does the number of bonds determine what type of fat it will be?

A

No double bond - saturated fat
Double bond present - unsaturated fat
one double bond = monounsaturated fat
more than one double bond = polyunsaturated fat

35
Q

Phospholipids

A

Glycerol + 2 fatty acid tail + phosphate group

  • membrane structural components: phospholipid bilayers
  • hydrophilic head because of the phosphate
  • hydrophobic tail because of the hydrocarbons
36
Q

Cholesterol

A
  • 4 hydrocarbon rings + hydroxyl group + hydrocarbon tail
  • hydrophobic
  • function as hormones and membrane components
37
Q

Factors that affect membrane fluidity

A

Chain Length: Shorter chain, Higher fluidity
Chain Saturation: Double Bond, Increase fluidity
Temperature: High temperature, Increase fluidity
Cholesterol: More cholesterol, Decrease fluidity (generally)

38
Q

What are Amino Acids? What makes an amino acids?

A

Monomers that makes up protein; building block of proteins
Carboxylic Acid group + central alpha carbon +amino group
- All amino acids have a carboxylic acid and amino group

39
Q

What determines the identity of an amino acid?

A

The R group connected to the central alpha carbon.

40
Q

What binds amino acids together? How does the binding work?

A

Peptide bond binds amino acids together to make polypeptides. The peptide bond binds the hydroxyl in the carboxyl terminus and a hydrogen in the nitrogen terminus to release a water molecule to bind it. (Condensation Reaction)

41
Q

Non-Polar amino acids

A

R Groups are nonpolar

Ex: Tryptophan and Menthionie

42
Q

Uncharged Polar Amino Acids

A

R Group is polar

Ex: Tyrosine contains an OH that makes the group polar

43
Q

Cysteine

A

Only amino acid that is reactive to sulfhydrl group.

  • can form disulfide bond
  • non polar
44
Q

Charged Amino Acid

A

Amino acid with a ionized R group

Ex: Aspartic acid and Glutamic acid has an oxygen anion on their carboxyl end

45
Q

Non –proteinogenic Amino Acids

A

Amino acid that does not get incorporated into proteins

- Ex: Gamma-aminobutyric acid: main inhibitory neurotransmitter in the nervous system

46
Q

What are Nucleotides?

A

Basic building block of nucleic acids

47
Q

What makes up a nucleotide?

A

Phosphate Group + Pentose (5 carbon Ring) + Nitrogenous Base

48
Q

Nucleotides vs Nucleosides vs Nucleic Acid

A

Nucleotides: Monomers of Nucleic Acid
Nucleoside: Component of nucleotide: sugar + nitrogenous base. Nucleotide are nucleoside with phosphate groups.
Nucleic Acid: Polymers of nucleotides

49
Q

How does nucleotide relate to energy?

A

ATP can be made with a ribonucleoside triphosphate (3 phosphate, ribose, adenine). Breaking the phosphate bond through hydrolysis reaction will release a large amount of energy.

50
Q

Functions of Nucleotides

A
  • Energy Carrier (ATP)
  • Signaling Molecules
  • Storage genetic information
51
Q

What joins nucleotides together to form nucleic acids? How does it work?

A

Phosphodiester bond join nucleotides together.

Nucleic acids have structural polarity. Because the phosphate group is polar, one of the free hydroxyl of the phosphate can bind to 5’ end bonds on one side and a 3’ end of the next sugar on the other side.

52
Q

DNA vs RNA

A

Sugar base
RNA: Hydroxyl on 2’ end
DNA: Oxygen on 2’ end

Nitrogenous Base
RNA: adenine, uracil, guanine, cytosine
DNA: adenine, thymine, guanine, cytosine

Structure
RNA: Mostly single stranded
DNA: Mostly double stranded

53
Q

What is the nitrogenous base pairing for DNA to be a double helix?

A
  1. Purine will always pair with pyrimidine

Adenine - Thymine (DNA) or Uracil (RNA)
- two hydrogen bonds

Guanine - Cytosine
- three hydrogen so it will be more stable

54
Q

How does DNA being a double helix contribute to DNA replication?

A

The double helix unwinds and each separated strand is used as a parent template to synthesize new strands.

55
Q

How does DNA contribute to storing and transferring genetic material?

A

Central Dogma
-Genetic information is carried in the linear sequence of nucleotides in DNA. To transfer genetic material, the DNA unwinds for RNA to be made (transcription). Then, the RNA is translated into amino acids, resulting proteins.