Chemical Carcinogenesis

Question 1

Initiator

Answer 1

an agent capable only of initiating cells, also called incomplete carcinogen (irreversible, DNA modification)

Question 2

Promoter

Answer 2

An agent capable of causing expansion of initiated cell clones (reversible, non-DNA-modifying)

Question 3

Progressor

Answer 3

An agent capable of converting an initiated cell or cell in the stage of promotion to potentially malignant cell

Question 4

Complete Carcinogen

Answer 4

An agent possessing the ability to induce cancer from normal cells, usually with properties of initiating, promoting, and progressing

Question 5

Genotoxicity

Answer 5

Covers a broad range of DNA damage

Question 6

Mutagenicity

Answer 6

Mutations caused by toxic agents on DNA and chromosome, which are usually transmissible from generation to generation

Question 7

Genetic alterations by genotoxic agents

Answer 7

DNA Damage, Gene Mutation, Chromosomal aberrations

Question 8

DNA Damage

Answer 8

Many types of DNA Damage induced by exogenous and endogenous genotoxic agents