CHEM FINAL (DRUGS) Flashcards
Produced in the pancreas;
Necessary for glucose to enter cells from the bloodstream
Insulin
Protein that reacts to glucose;
Measured to indicate glucose levels over 2-3 months
hemoglobin A1c
“bad cholesterol”
Healthy level is > 3
LDL
“good cholesterol”
Healthy level is > 1
HDL
Gene whose carriers are prone to high cholesterol and alzheimer’s disease; More common (20-30% occurrence) in African and Caucasians
APOE4
Statin drug that lowers cholesterol;
Most prescribed drug for cholesterol;
NNT = ~150
Lipitor
A molecule that can build up in the body (to toxic levels);
Easily metabolized in the body with B vitamins
Homocysteine
Measure inflammation via this protein;
High levels correlated with heart attack risk;
Very high levels indicate bacterial infection
C-reactive protein
Increased intake of this reduces blood pressure;
Suggested daily intake = 4500mg
Potassium
Decreased intake of this reduces blood pressure;
Optimal daily intake = 1500mg, but average = 3400mg
Sodium
Increases the amount of urine, which reduces the amount of fluid in the bloodstream, lowers pressure on artery walls
Diuretics
Blocks the production of angiotensin II, a chemical produced to raise blood pressure
ACE inhibitors
Blocks the effect of adrenalin, which is produced by the adrenal glands when blood pressure needs to be elevated and more glucose needs to be metabolized
Beta blockers
They act by dilating the arteries and reducing resistance to the flow of blood
Calcium channel blockers
They lower BP by blocking angiotensin from binding to “receptor sites” in blood vessels, thus stopping the angiotensin from tightening the arteries and raising the BP
Angiotensin receptor antagonists
Used to treat the symptoms of angina by dilating the blood vessels;
Introduced into the bloodstream under the tongue (tablet or spray)
Nitroglycerin
Used to reduce the risk of angina (2)
beta blockers and calcium antagonists
May effectively reduce the risk of angina;
Combines with hydrogen peroxide in the body to form nitric oxide, which dilates blood vessels
Arginine
Active ingredient in Digitalis, the extract of the foxglove plant
Digoxin
Used to treat congestive heart failure (3)
ACE inhibitors, beta blockers, and diuretics
Levels of this enzyme are reduced in hearts of congestive heart failure patients
Coenzyme Q10
An brand name diuretic
Dyazide
An brand name ACE inhibitor
Vasotec
An brand name beta blocker
Inderal
An brand name calcium channel blocker
Adalat
An brand name angiotensin receptor antagonist
Valsartan
An antiarrhythmic medication, which can control the rate of the heartbeat
Amiodarone
Regular intake of this reduces the risk of blood coagulation, but increase other risks
Aspirin
MONA treatment for heart attack:
1) to reduce the pain
2) to increase these levels in the blood
3) to dilate the blood vessel
4) to prevent clot formation/coagulation
1) Morphine
2) Oxygen
3) Nitroglycerin
4) Aspirin
These two molecules are released when cells in the heart are dying
troponin and creatine kinase
Two more powerful blood-thinners than aspirin
Plavix and Heparin
Use of this to treat present blood clot
thrombolytic medication
An brand name thrombolytic
Activase
Used of this to treat present blood clot (2)
ACE inhibitors and beta blockers
A brand name drug sometimes used in drug-eluting stents;
reduces inflammation and prevents clots from forming
Sirolimus
Two brand name drugs used after bypass surgeries to reduce the chance of blood clot formation
Dipyridamole or Abciximab
Anti-rejection drug used after heart transplants;
It is an immunosuppressant
cyclosporine
Types of stem cells (5)
1) skeletal myoblasts
2) endothelial progenitor cells
3) mesenchymal stem cells
4) cardiac progenitor cells
5) pluripotent stem cells
Two molecules being studied as an alternative to stem cells;
Emblematic of the paracrine effect
VAG-f and RNA
Used to prime stem cells so that they don’t die too quickly
Oxytocin
First hormone ever isolated;
Secreted from the intestine to signal the pancreas
secretin
Hormone released from the pituitary;
Causes the breast to lactate
Prolactin
Hormone released from the pituitary;
The technical name for growth hormone
Somatotropin
Injections of this can increase cow milk yield by 20%
Bovine somatotropin (BGH)
Hormone released from the pituitary;
Stimulates adrenal glands to produce adrenaline, cortisol & corticosterone, and aldosterone
Adrenocorticotropic hormone (ACTH)
Two hormones released from the adrenals;
Related to healing and anti-inflammation
cortisol & corticosterone
Hormone released from the adrenals;
Controls the mineral composition of the bloodstream
aldosterone
Fight/flight/freeze hormone;
Raises BP by increasing glucose levels
adrenaline
Three hormones produced in the adrenal gland cortex (i.e. the outer area)
cortisol, corticosterone, and aldosterone (i.e. the corticosteroids)
Hormone produces in the medulla
adrenaline
Synthetic corticosteroid used to treat Addison’s disease
hydrocortisone
Hormone released from the pituitary;
Causes the release of eggs by the ovaries
Follicle stimulating hormone (FSH)