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Chemistry Fall 24' > Chem Exam 4 > Flashcards

Chem Exam 4 Flashcards

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1
Q

Which of the following statements is true concerning buffers?

  • Buffers can contain a weak acid and its conjugate base
  • Buffers resist change in pH when additional acids or bases are added
  • Buffers have a limit, called buffer capacity, of how much additional acid or base can be added.
  • Buffers can contain a weak base and its conjugate acid
  • All of the above statements are true when concerning buffers
A
  • All of the above statements are true when concerning buffers
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2
Q

What is the conjugate acid of HCO3⁻?

  • H3O+
  • OH⁻
  • H2CO3
  • H2O
  • CO32-
A
  • H2CO3
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3
Q

Which of the following is not a chemical interaction consideration for drug binding?

  • Hydrophobic interactions
  • Electrostatic interactions
  • Agostic interactions
  • Stereospecific interactions
A
  • Agostic interactions
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3
Q

Which of the following is a Br∅nsted-Lowry base?
* CH4
* HCN
* NH3
* Cl2

A
  • NH3
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4
Q

Which term is used to describe the extent to which a drug produces its desired effect?

  • Affinity
  • Efficacy
  • Toxicity
  • Potency
A
  • Efficacy
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4
Q

Which drug category binds irreversibly to a receptor?

  • Non-competetive antagonist
  • Endogenous agonist
  • Exogenous agonist
  • Competetive antagonist
A
  • Non-competetive antagonist
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5
Q

Which of the following does not affect the bioavailability of a drug?

  • Drug temperature
  • Drug stability
  • Drug metabolism
  • Drug interactions
  • Molecular weight of a drug
A
  • Drug temperature
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5
Q

How many hydrogen bond donors are in magnocurarine?
___

A

2

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5
Q

Would the following compound (logP = 2.97) be considered a good drug candidate? (Select All)

  • The compound has too many total hydrogen bond donors and acceptors.
  • The compound would be considered a good drug candidate.
  • The logP for the compound is too low.
  • The molecular weight of the compound is too high.
  • The compound contains multiple structural alerts (toxicophores)
  • The compound contains one structural alerts (toxicophores)
  • The compound contains no structural alerts (toxicophores)
  • The compound would not be considered a good drug candidate.
  • The logP for the compound is too high.
A
  • The compound would be considered a good drug candidate.
  • Would the following compound (logP = 2.97) be considered a good drug candidate? (Select All)
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6
Q

Magnocurarine is a natural product isolated from a flowering herb that has been investigated for its potential as a muscle relaxant. From the structure below, which portion would contain the strongest intermolecular force?

  • 3
  • 4
  • 1
  • 2
A
  • 2
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7
Q

How many hydrogen bond acceptors are in magnocurarine?

A

3

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7
Q

Which of the following solutions would have the most basic pH? Assume that they are all 0.10 M in acid at 25C. The acid is followed by its Ka value.

  • HNO2, 4.6 × 10-4
  • HF, 3.5 × 10-4
  • HCHO2, 1.8 × 10-4
  • HClO2, 1.1 × 10-2
  • HCN, 4.9 × 10-10
A
  • HCN, 4.9 × 10-10
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8
Q

Which of the following statements would be true about imipenem (log P = -3.80)?

  • Imipenem is fairly lipid soluble, but would still require active transport to cross membranes.
  • Imipenem has high water solubility requiring active transport to cross membranes.
  • Imipenem is fairly lipid soluble and would have no trouble crossing membranes.
  • Imipenem has high water solubility and would be able to cross membranes via diffusion.
A
  • Imipenem has high water solubility requiring active transport to cross membranes.
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8
Q

Determine the pH of a 0.023 M HNO3 solution.

A

Correct answer:
1.638272164

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8
Q

How many hydrogen bond acceptors are in imipenim?

A

7

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8
Q

How many hydrogen bond donors are in imipenim?

A

4

9
Q

Determine the pH of a 0.265 M HClO solution. The Ka of HClO is 2.9 × 10^-8. (Report your answer to two decimal places)

A

Correct answer:
4.06

9
Q

Determine the pH of a 0.188 M NH3 solution at 25C. (Kb = 1.72 x 10^-5) (Report your answer to two decimal places).

A

Correct answer:
11.25

9
Q

What is the percent ionization for the acidic drug thiopental (pKa = 7.55) in the blood stream (pH = 7.35)? (Report your answer to the nearest percent; no decimal places).

A

Correct answer:
39

10
Q

Calculate the pH of a 7.8 × 10^-6 M LiOH solution (Report your answer to two decimal places)

A

Correct answer:
8.89

10
Q

What is the pH of a buffer solution that is 0.15 M in HNO2 and 0.40 M in NaNO2 (Ka = 4.70 x 10^-4)? (Report your answer to two decimal places).

A

Correct Answer:
3.70 to 3.80 inclusive

10
Q

Calculate the pH of a buffer that is 0.0909 M NH3 and 0.00909 M NH4Cl (Ka = 5.8 × 10^-10 ). (Report your answer to two decimal places).

A

Correct answer:
10.24

11
Q

What is the pH of a buffer that is 0.25 M in guanidine and 5.50 M in guanidine hydrochloride (Ka = 2.5 x 10^-14)? (Report your answer to two decimal places).

A

Correct answer:
12.26

12
Q

Calculate the blood pH for a patient exhibiting [bicarbonate] = 29 mM and blood CO2 levels = 47 mmHg (Report your answer to two decimal places).

A

Correct answer:
7.41

12
Q

What is the pH of a 1.25 x 10^-3 solution of Ca(OH)2? Report your answer to two decimal places (i.e. 3.25).

A

Correct Answer:
11.35 to 11.45 inclusive

12
Q

What is the percent ionization of the basic drug codeine (pKa = 8.2) in the intesitines (pH = 7.8)? (Report your answer to the nearest percent; no decimal places).

A

Correct answer:
71

12
Q

A patient has plasma [bicarbonate] = 47 mM and blood CO2 pressure = 43 mmHg; what would the effect be on their blood pH if the blood CO2 levels were increased?

  • The blood pH would remain the same.
  • The blood pH would decrease.
  • The blood pH would increase.
  • The blood pH would decrease.
A
  • The blood pH would decrease.
13
Q

What is the pH of 0.0630 solution of formic acid (KA = 1.77 x 10^-4)? Report your answer to two decimal places (i.e. 3.25).

A

Correct answer:
2.48

14
Q

What is the pH of a 0.612 M solution of pyridine (Kb = 1.78 x 10^-9)? (Report your answer to two decimal places).

A

Correct answer:
9.52

15
Q

Calculate the percent ionization for the acidic drug phenobarbital (pKA = 7.30) in the blood stream (pH = 7.4). Report your answer to two decimal places (i.e. 3.25)

A

Correct answer:
55.73

15
Q

How many hydrogen bond acceptors are found in the following compound?

A

7

15
Q

For the following compound, what would the strongest intermolecular force it would exhibit?

  • Hydrogen Bonding
  • van der Waals
  • Ion-Dipole
  • Ion-Ion
  • Dipole-Dipole
A
  • Hydrogen Bonding
15
Q

Calculate the pH of a buffer that is 1.25 M imidazole and 0.500 M imidazole hydrochloride (KA = 1.02 x 10^-7). Report you answer to two decimal places (i.e. 3.25).

A

Correct answer:
7.39

15
Q

Would the following compound (logP = 6.29) be considered a good drug candidate? (Select All)

  • The compound has too many total hydrogen bond donors and acceptors.
  • The compound has high water solubility and would use diffusion to cross membranes.
  • The compound has high lipid solubility and would use diffusion to cross membranes.
  • The compound contains multiple structural alerts (toxicophores)
  • The compound contains one structural alerts (toxicophores)
  • The compound would have high lipid solubility requiring active transport.
  • The compound would not be considered a good drug candidate.
  • The compound contains no structural alerts (toxicophores)
  • The logP for the compound is too high.
  • The compound would be considered a good drug candidate.
  • The compound would have high water solubility requiring active transport.
  • The molecular weight of the compound is too high.
  • The logP for the compound is too low.
A
  • The compound would have high lipid solubility requiring active transport.
  • The compound would not be considered a good drug candidate.
  • The compound contains no structural alerts (toxicophores)
  • The logP for the compound is too high.
  • The molecular weight of the compound is too high.
16
Q

How many hydrogen bond donors are found in the following compound?

A

2

16
Q

Tipranavir is an acidic drug used to treat HIV. If Tipranavir has a KA = 1.10 x 10^-6, how much of the drug would be ionized in the stomach (pH = 2)? Report your answer to two decimal places (i.e. 3.25).

A

Correct answer:
0.01

17
Q

Tipranavir is an acidic drug used to treat HIV. If Tipranavir has a KA = 1.10 x 10^-6, how much of the drug would be ionized in the duodenum (pH = 6)? Report your answer to two decimal places (i.e. 3.25).

A

Correct answer:
52.38

18
Q

Tipranavir is an acidic drug used to treat HIV. If Tipranavir has a KA = 1.10 x 10^-6, how much of the drug would be ionized in the large intestine (pH = 7.8)? Report your answer to two decimal places (i.e. 3.25).

A

Correct answer:
98.58

19
Q

Tipranavir is an acidic drug used to treat HIV. If Tipranavir has a KA = 1.10 x 10^-6, how much of the drug would be ionized in the blood stream (pH = 7.4)? Report your answer to two decimal places (i.e. 3.25).

A

Correct answer:
96.51

Chemistry Fall 24' (8 decks)

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