Chem Exam 4 Flashcards
Which of the following statements is true concerning buffers?
- Buffers can contain a weak acid and its conjugate base
- Buffers resist change in pH when additional acids or bases are added
- Buffers have a limit, called buffer capacity, of how much additional acid or base can be added.
- Buffers can contain a weak base and its conjugate acid
- All of the above statements are true when concerning buffers
- All of the above statements are true when concerning buffers
What is the conjugate acid of HCO3⁻?
- H3O+
- OH⁻
- H2CO3
- H2O
- CO32-
- H2CO3
Which of the following is not a chemical interaction consideration for drug binding?
- Hydrophobic interactions
- Electrostatic interactions
- Agostic interactions
- Stereospecific interactions
- Agostic interactions
Which of the following is a Br∅nsted-Lowry base?
* CH4
* HCN
* NH3
* Cl2
- NH3
Which term is used to describe the extent to which a drug produces its desired effect?
- Affinity
- Efficacy
- Toxicity
- Potency
- Efficacy
Which drug category binds irreversibly to a receptor?
- Non-competetive antagonist
- Endogenous agonist
- Exogenous agonist
- Competetive antagonist
- Non-competetive antagonist
Which of the following does not affect the bioavailability of a drug?
- Drug temperature
- Drug stability
- Drug metabolism
- Drug interactions
- Molecular weight of a drug
- Drug temperature
How many hydrogen bond donors are in magnocurarine?
___
2
Would the following compound (logP = 2.97) be considered a good drug candidate? (Select All)
- The compound has too many total hydrogen bond donors and acceptors.
- The compound would be considered a good drug candidate.
- The logP for the compound is too low.
- The molecular weight of the compound is too high.
- The compound contains multiple structural alerts (toxicophores)
- The compound contains one structural alerts (toxicophores)
- The compound contains no structural alerts (toxicophores)
- The compound would not be considered a good drug candidate.
- The logP for the compound is too high.
- The compound would be considered a good drug candidate.
- Would the following compound (logP = 2.97) be considered a good drug candidate? (Select All)
Magnocurarine is a natural product isolated from a flowering herb that has been investigated for its potential as a muscle relaxant. From the structure below, which portion would contain the strongest intermolecular force?
- 3
- 4
- 1
- 2
- 2
How many hydrogen bond acceptors are in magnocurarine?
3
Which of the following solutions would have the most basic pH? Assume that they are all 0.10 M in acid at 25C. The acid is followed by its Ka value.
- HNO2, 4.6 × 10-4
- HF, 3.5 × 10-4
- HCHO2, 1.8 × 10-4
- HClO2, 1.1 × 10-2
- HCN, 4.9 × 10-10
- HCN, 4.9 × 10-10
Which of the following statements would be true about imipenem (log P = -3.80)?
- Imipenem is fairly lipid soluble, but would still require active transport to cross membranes.
- Imipenem has high water solubility requiring active transport to cross membranes.
- Imipenem is fairly lipid soluble and would have no trouble crossing membranes.
- Imipenem has high water solubility and would be able to cross membranes via diffusion.
- Imipenem has high water solubility requiring active transport to cross membranes.
Determine the pH of a 0.023 M HNO3 solution.
Correct answer:
1.638272164
How many hydrogen bond acceptors are in imipenim?
7
How many hydrogen bond donors are in imipenim?
4
Determine the pH of a 0.265 M HClO solution. The Ka of HClO is 2.9 × 10^-8. (Report your answer to two decimal places)
Correct answer:
4.06
Determine the pH of a 0.188 M NH3 solution at 25C. (Kb = 1.72 x 10^-5) (Report your answer to two decimal places).
Correct answer:
11.25
What is the percent ionization for the acidic drug thiopental (pKa = 7.55) in the blood stream (pH = 7.35)? (Report your answer to the nearest percent; no decimal places).
Correct answer:
39
Calculate the pH of a 7.8 × 10^-6 M LiOH solution (Report your answer to two decimal places)
Correct answer:
8.89
What is the pH of a buffer solution that is 0.15 M in HNO2 and 0.40 M in NaNO2 (Ka = 4.70 x 10^-4)? (Report your answer to two decimal places).
Correct Answer:
3.70 to 3.80 inclusive
Calculate the pH of a buffer that is 0.0909 M NH3 and 0.00909 M NH4Cl (Ka = 5.8 × 10^-10 ). (Report your answer to two decimal places).
Correct answer:
10.24
What is the pH of a buffer that is 0.25 M in guanidine and 5.50 M in guanidine hydrochloride (Ka = 2.5 x 10^-14)? (Report your answer to two decimal places).
Correct answer:
12.26
Calculate the blood pH for a patient exhibiting [bicarbonate] = 29 mM and blood CO2 levels = 47 mmHg (Report your answer to two decimal places).
Correct answer:
7.41
What is the pH of a 1.25 x 10^-3 solution of Ca(OH)2? Report your answer to two decimal places (i.e. 3.25).
Correct Answer:
11.35 to 11.45 inclusive
What is the percent ionization of the basic drug codeine (pKa = 8.2) in the intesitines (pH = 7.8)? (Report your answer to the nearest percent; no decimal places).
Correct answer:
71
A patient has plasma [bicarbonate] = 47 mM and blood CO2 pressure = 43 mmHg; what would the effect be on their blood pH if the blood CO2 levels were increased?
- The blood pH would remain the same.
- The blood pH would decrease.
- The blood pH would increase.
- The blood pH would decrease.
- The blood pH would decrease.
What is the pH of 0.0630 solution of formic acid (KA = 1.77 x 10^-4)? Report your answer to two decimal places (i.e. 3.25).
Correct answer:
2.48
What is the pH of a 0.612 M solution of pyridine (Kb = 1.78 x 10^-9)? (Report your answer to two decimal places).
Correct answer:
9.52
Calculate the percent ionization for the acidic drug phenobarbital (pKA = 7.30) in the blood stream (pH = 7.4). Report your answer to two decimal places (i.e. 3.25)
Correct answer:
55.73
How many hydrogen bond acceptors are found in the following compound?
7
For the following compound, what would the strongest intermolecular force it would exhibit?
- Hydrogen Bonding
- van der Waals
- Ion-Dipole
- Ion-Ion
- Dipole-Dipole
- Hydrogen Bonding
Calculate the pH of a buffer that is 1.25 M imidazole and 0.500 M imidazole hydrochloride (KA = 1.02 x 10^-7). Report you answer to two decimal places (i.e. 3.25).
Correct answer:
7.39
Would the following compound (logP = 6.29) be considered a good drug candidate? (Select All)
- The compound has too many total hydrogen bond donors and acceptors.
- The compound has high water solubility and would use diffusion to cross membranes.
- The compound has high lipid solubility and would use diffusion to cross membranes.
- The compound contains multiple structural alerts (toxicophores)
- The compound contains one structural alerts (toxicophores)
- The compound would have high lipid solubility requiring active transport.
- The compound would not be considered a good drug candidate.
- The compound contains no structural alerts (toxicophores)
- The logP for the compound is too high.
- The compound would be considered a good drug candidate.
- The compound would have high water solubility requiring active transport.
- The molecular weight of the compound is too high.
- The logP for the compound is too low.
- The compound would have high lipid solubility requiring active transport.
- The compound would not be considered a good drug candidate.
- The compound contains no structural alerts (toxicophores)
- The logP for the compound is too high.
- The molecular weight of the compound is too high.
How many hydrogen bond donors are found in the following compound?
2
Tipranavir is an acidic drug used to treat HIV. If Tipranavir has a KA = 1.10 x 10^-6, how much of the drug would be ionized in the stomach (pH = 2)? Report your answer to two decimal places (i.e. 3.25).
Correct answer:
0.01
Tipranavir is an acidic drug used to treat HIV. If Tipranavir has a KA = 1.10 x 10^-6, how much of the drug would be ionized in the duodenum (pH = 6)? Report your answer to two decimal places (i.e. 3.25).
Correct answer:
52.38
Tipranavir is an acidic drug used to treat HIV. If Tipranavir has a KA = 1.10 x 10^-6, how much of the drug would be ionized in the large intestine (pH = 7.8)? Report your answer to two decimal places (i.e. 3.25).
Correct answer:
98.58
Tipranavir is an acidic drug used to treat HIV. If Tipranavir has a KA = 1.10 x 10^-6, how much of the drug would be ionized in the blood stream (pH = 7.4)? Report your answer to two decimal places (i.e. 3.25).
Correct answer:
96.51
