CHD associations Flashcards
Carpenter syndrome
PDA VSD ASD PS TOF TGA
Cat Eye Syndrome
TAPVR
Persistent left SVC
CHARGE association (50-70%)
TOF DORV VSD ASD PDA Right sided aortic arch
cornelia de Lange syndrome
VSD most common
DiGeorge syndrome
Aortic arch abnormalities (right arch, interrupted aorta, truncus arteriosus)
TOF
PA
Ehlers-Danlos syndrome
Aortic root dilatation
Mitral valve prolapse
Ellis-van Creveld Syndrome
Common atrium
Glycogen storage IIa (Pompe)
Hypertrophic cardiomyopathy (secondary to glycogen deposition)
Goldenhar syndrome
VSD
PDA
TOF
CoA
Holt-Oram syndrome (>50%)
ASD most common
Homocystinuria
Arterial and Venous thromboses
Medial degeneration of aorta and elastic artery
Hurler Syndrome
Thickened valves (especially mitral)
Coronary artery disease
Hypertrophic cardiomyopathy
Klinefelter
ToF
MV prolapse
Klippel-Feil sequence
VSD
Marfan syndrome
Dilated aorta and aortic root
Aortic aneurysm
MV prolapse
Meckel-Gruber Syndrome
ASD VSD PDA CoA PS
Noonan Syndrome (>50%)
Dysplastic or thickened pulmonary valve LFH (secondary to local anterior septal wall hypertrophy, less often diffuse hypertrophy) ASD VSD PDA Branch stenosis of pulmonary arteries
Rubenstein-Taybi syndrome
PDA
VSD
ASD
TAR syndrome (thrombocytopenia, absent radius)
TOF
ASD
Trisomy 13 (Patau syndrome) (80-90%)
VSD or PDA
<50% with other cardiac anomalies
Trisomy 18 (Edward Syndrome) (95-99%)
VSD PDA PS CoA TOF Polyvalvular disease
Trisomy 21 (40-50%
Complete AVC > VSD > PDA
ASD
TOF
Turner syndrome (45 XO) (35%)
Bicuspid aortic valve CoA Aortic stenosis MV prolapse Aortic dissection Hypertension later in life
VACTERL association (50%)
VSD > TOF
CoA
Williams syndrome (50-70%)
Supravalvular subaortic stenosis > PPAS
PS
Coxsackie B virus
Myocarditis
Parvovirus B19
Myocarditis
Rubella
PDA PPS PS AS ToF Myocarditis
Aspirin
Pulmonary hypertension
Ethanol
VSD
ASD
ToF
CoA
Indomethacin
Premature closure of PDA
Lithium
Ebstein’s anomaly
Retinoic acid
TGA ToF DORV Truncus arteriosus Artic arch abnormalities HLHS
SSRI’s
Pulmonary hypertension
Thalidomide
Conotruncal malformations
Trimethadione
VSD ASD TGA ToF HLHS TA
Valproic acid
ASD VSD AS PA/IVS CoA ToF
Warfarin
PDA
PPS
SLE
Congenital heart block (1-2%), recurrence risk 16-40%
Risk for heart block independent of severity of maternal disease
30-60% of mothers with infant who has complete heart block will have SLE
Diabetes mellitus
D-TGA, VSD, CoA, ventricular hypertrophy (especially if poor glucose control in 3rd trimester)
Risk greater if insulin-dependent prior to pregnancy
Risk lower if normal HbA1C level
