Characteristic Lesions

Question 1

Durck Granulomas (perivascular ring hemorrhages)

Answer 1

Cerebral Malaria

Question 2

Mucopurulent exudate reminiscent of a volcano

Answer 2

C. Difficile

Question 3

Asexual intracellular parasite with Hemozoin

Answer 3

Plasmodium

Babesia - without hemozoin

Question 4

Nurse cells (skeletal muscle cells with loss of striations, formation of collagenous capsule, development of new blood vessels)

Answer 4

Trichinosis

Question 5

Meyers-Kouwenar Bodies (dead worms surrounded by hyaline, eosinophilic precipitates embedded in small epithelioid granulomas)

Answer 5

Filariasis

Question 6

Mazzotti Reaction (accentuation of keratitis with antifilarial treatment)

Answer 6

Onchocerciasis

Question 7

Ring sideroblasts, Saturnine gout, peripheral demyelinating neuropathy

Answer 7

Lead Poisoning

Question 8

Itai Itai Disease (osteoporosis and osteomalacia with associated renal disease)

Answer 8

Cadmium poisoning

Question 9

Homer-Wright Pseudorosettes

Answer 9

Neuroblastoma

Question 10

Blueberry muffin baby

Answer 10

Neuroblastoma

Question 11

Gonadal dysgenesis
Early onset nephropathy (diffuse mesangial sclerosis)
Increased risk for Wilms tumor

Answer 11

Denys-Drash Syndrome

Question 12

Organomegaly
Macroglossia 
Hemihypertrophy
Omphalocele
Adrenal cytomegaly

Answer 12

Beckwith-Wiedemann Syndrome (WT2 gene)

Question 13

Aschoff bodies (granulomatous lesions with T lymphocytes, plasma cells, and caterpillar cells seen in all layers of the heart)

Answer 13

RHD

Question 14

MacCallum Plaques

Answer 14

RHD

Subendocardial thickening due to regurgitant jets

Question 15

Spider Cells (cytoplasmic strands from nucleus to the surface membrane)

Answer 15

Rhabdomyoma

Question 16

Auer Rods (needle like azurophilic granules)
Faggot Cells (w/ numerous Auer rods)

Answer 16

Acute Promyelocytic Leukemia

Question 17

Smudge cells/basket cells

Answer 17

CLL

Abnormally fragile lymphocytes

Question 18

Lymphohistiocytic popcorn RS cells

Answer 18

Lymphocyte prediminant HL

Question 19

Starry sky

Answer 19

Burkitt Lymphoma

Question 20

Sezary Cells / Buttock cells (T cells with cerebriform nuclei)

Pautrier microabscesses

Answer 20

Cutaneous T Cell Lymphoma/ Mycosis Fungoides

Question 21

M Protein

Bence Jones Proteinuria

Answer 21

Multiple Myeloma

Question 22

Russell Bodies (PAS+ cytoplasmic inclusions)
Dutcher bodies (PAS+ nuclear inclusions)

Answer 22

Multiple Myeloma

Question 23

Ringed sideroblasts
Pseudo Pelget Huet Cells (PMN with only 2 lobes)
Pawn ball megakaryocytes (with multiple separated nuclei)

Answer 23

MDS

Question 24

Birbeck granules (pentalaminar racket shaped granules with Langerin protein)

Answer 24

Langerhan Cells Histiocytosis

Question 25

Heinz bodies

Bite cells

Answer 25

G6PD Deficiency

Question 26

Codocytes

Howell Jolie Bodies (nuclear remnants in asplenic patients)

Answer 26

Sickle Cell Anemia

Question 27

Increased Reid Index > 0.4

Answer 27

Chronic bronchitis

Question 28

Curshmann spirals (whorls of shed epithelium)
Charcot Leyden crystals

Answer 28

Status Asthmaticus

Question 29

Egg shell calcifications of lymph nodes

Answer 29

Silicosis

Question 30

Schaumann bodies (concretions of calcium and proteins)
Asteroid bodies (stellate inclusions in giant cells)

Answer 30

Sarcoidosis

Question 31

Small cells with salt and pepper chromatin
Azzopardi effect (Basophilic staining of vascular walls)

Answer 31

Small cell lung Ca

Question 32

Double layer of oncocytic epithelial Cells with dense lymphoid stroma (may have germinal centers)

Answer 32

Warthin Tumor (Papillary cystadenoma lymphomatosum)

Question 33

Florid duct lesion
Mallory denk bodies
Micronodular cirrhosis with hepatomegaly

Answer 33

Primary Biliary Cirrhosis

Question 34

Spike and dome appearance on EM

Subepithelial deposits along GBM

Answer 34

MGN

Question 35

Basket weave appearance of GBM on EM

Answer 35

Alport Syndrome