Chapter_058 Male Reproductive Problems Flashcards
What is Benign Prostatic Hyperplasia (BPH)?
Enlargement of the prostate gland leading to disruption of urine outflow from bladder through urethra.
Almost 50% of men will have signs of BPH by age 50; 70% by ages 60 to 69.
What are the lower urinary tract symptoms (LUTS) associated with BPH?
- Difficulty starting a urine stream
- Decreased/weaker flow of urine
- Urinary frequency
Symptoms worsen as obstruction increases.
What hormonal changes may contribute to BPH?
- Excessive accumulation of DHT in prostate cells
- Increased proportion of estrogen over testosterone in blood
Hormonal changes from aging process may contribute.
In which part of the prostate does BPH develop?
Develops in the inner part of the prostate—’transition zone’.
What are the risk factors for BPH?
- Aging
- Obesity
- Lack of physical activity
- High intake of red meat and animal fat
- Alcohol use
- Erectile dysfunction (ED)
- Smoking
- Diabetes
- Family history
First-degree relative is significant.
What are irritative symptoms of LUTS?
- Nocturia
- Urinary frequency
- Urgency
- Dysuria
- Bladder pain
- Incontinence
Inflammation or infection may cause these symptoms.
What are obstructive symptoms of LUTS?
- Decrease in caliber and force of urinary stream
- Difficulty initiating a stream
- Intermittency
- Dribbling at end of urination
Caused by prostate enlargement.
What is the purpose of the AUA-SI for BPH?
To assess voiding symptoms and provide guidelines for treatment.
What is acute urinary retention?
Sudden and painful inability to urinate.
Treatment involves catheter insertion or surgery if severe.
What complications can arise from BPH?
- Urinary tract infections (UTI)
- Pyelonephritis
- Sepsis
- Bladder calculi
- Renal failure
Caused by hydronephrosis or bladder damage.
What diagnostic studies are used for BPH?
- Digital rectal exam (DRE)
- Urinalysis
- PSA level
- Serum creatinine
- Renal ultrasound
- Transrectal ultrasound (TRUS)
- Uroflowmetry
- Cystoscopy
- Urodynamic studies
Includes assessments for size, symmetry, and consistency.
What are the goals of treatment for BPH?
- Restore bladder drainage
- Relieve symptoms
- Prevent/treat complications.
What are the two main classes of drug therapy for BPH?
- 5α-Reductase inhibitors
- α-adrenergic receptor blockers
More effective when used in combination.
What is the function of 5α-Reductase inhibitors?
Blocks enzyme necessary for conversion of testosterone to DHT, decreasing the size of the prostate gland.
What are some examples of 5α-Reductase inhibitors?
- Finasteride (Proscar)
- Dutasteride (Avodart)
- Jalyn (finasteride plus tamsulosin).
What is the role of α-adrenergic receptor blockers?
Promote smooth muscle relaxation and facilitate urinary flow through urethra.
What are some examples of α-adrenergic receptor blockers?
- Alfuzosin (Uroxatral)
- Doxazosin (Cardura)
- Prazosin (Minipress)
- Terazosin (Hytrin)
- Tamsulosin (Flomax)
- Silodosin (Rapaflo).
What is photoselective vaporization of the prostate (PVP)?
Laser light used to vaporize prostate tissue, works well for larger prostate glands.
What is transurethral microwave therapy (TUMT)?
Outpatient procedure delivering heat via microwaves directly to prostate to relieve obstruction.
What is the goal of invasive treatments for BPH?
Surgical removal of prostate tissue to relieve obstruction.
What is transurethral resection of the prostate (TURP)?
Gold standard for obstructing BPH; surgical removal of prostate tissue through urethra.
What are potential postoperative complications of TURP?
- Bleeding
- Bladder spasms
- Urinary incontinence
- Infection.
What are the preoperative goals for patients undergoing TURP?
- Restore urinary drainage
- Resolve UTI
- Understand upcoming procedure and implications for sexual function.
What should be assessed in postoperative care for TURP?
- Complications such as bleeding, bladder spasms, urinary incontinence, and infection.