Chapter 9 - Sleeping & Waking Flashcards
endogenous circananual rhythm
self-generated rhythm that lasts about a year
endogenous circadian rhythm
self-generated rhythm that lasts abhout a day
name several circaidan rhythms
eating, drinking, urination, secretion of hormones, sensitivity to drugs, temperature, mood and more.
what evidence indicates that humans have an internal biological clock?
people who have lived in an environment with a light/dark schedule much different from 24 hours fail to follow that schedule and instead become wakeful and sleepy on about a 24hr basis.
can circadian rhythms persist without light?
yes.
what can reset circadian rhythms?
light is critical for resetting circadian rhythms.
zeitgeber
the stimulus that resets the circadian rhythm. (meaning “time-giver”)
what other zeitgebers are there?
tide (for marine animals), exercise, arousal, meals, and temperature.
how do the blind set circadian rhythms without light?
some use noise, temperature, meals and activity. others produce circadian rhythms a little longer than 24 horus.
why do people at the eastern edge of germany awaken earlier than those at the western edge on their weekends and holidays?
the sun rises about 30 min earlier at the eastern edge. the sun seems to control the wake/sleep schedules een when people follow the same clock time.
jet lag
disruption of circadian rhythms due to crossing time zones
symptoms of jet lag
sleepiness in the day, sleeplessness at night, depression and impaired concentration
phase-delay
the delay of circadian rhythms by traveling west. we stay awake later at night then wake late the next morning already partly adjusted to the new schedule
phase-advance
the advance of circadian rhythms by traveling east. we go to sleep earlier and wake earlier. it is harder to do both.
how does jet lag and stress affect the brain?
jet lag increases stress, stress increases cortisol. prolonged elevations of cortisol damage the hippocampus (important for memory)
suprachiasmatic nucleus (SCN)
located just above the optic chiasm. provides main control of circadian rhythms for sleep and temperature.
what does damage to the suprachiasmetic nucleus (SCN) cause
it causes the body’s rhythms to become erratic
what evidence strongly idicates that the SCN produces the circadian rhythm itself?
SCN cells produce a circadian rhythm even when isolated from the rest of the body. also, when transplanted, the recipient has the rhythm of the new SCN.
retinohypothalamic path
small branch of optic nerve which extends from retina to the SCN. axons alter SCN’s settings.
melanopsin
special retinal ganglion cells that make up the retinohypothalamic path. respond directly to light. help reset the SCN
PER and TIM
Period & Time. genes which promote sleep and inactivity based on feedback from several sets of neurons.
what could a mutation in PER cause?
a circadian rhythm shorter than 24 hours. sleepy in the evening, waking up early. also may suffer from depression
how do the proteins TIM and PER relate to sleepiness in the drosophilia fly?
the proteins remain low during most of the day, increasing in the evening promoting sleep. they also inhibit the genes that produce them so their level declines toward morning (promoting wakefulness)
pineal gland
an endocrine gland posterior to the thalamus. releases melatonin (mostly at night)