Chapter 9- Principles of drug disposition and drug interaction in horses Flashcards
What is the therapeutic index?
The ratio of the maximum therapeutic concentration to the minimum therapeutic concentration
What is the Minimum therapeutic concentration?
The plasma drug concentration where the onset of drug action is seen
How can the Maximum therapeutic concentration be achieved?
By allowing the drug concentration to increase until toxic effects
The intensity of drug effect increases with ____ until plateau is reached
Plasma drug concentration
What is acute tolerance to a drug?
Intensity of drug effect is less than expected at a normal dose
Why can acute tolerance happen?
Due to increase rate of distribution of drug to peripheral tissues
What is chronic tolerance?
When the intensity of drug diminishes after repeated dosing
Why can chronic tolerance happen?
Due to reduction in the number of receptors (down-regulation)
