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PSA > Chapter 9 > Flashcards

Chapter 9 Flashcards

1
Q

Type A vs type B drug reaction?

A

Type A reaction – common, predictable
and dose related.

Type B reactions (sometimes called
idiosyncratic) are bizarre and unexpected reactions related to gene/host/environmental interactions

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2
Q

What are the ADR of gentamicin and vancomycin?

A

nephrotoxicity

ototoxicity

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3
Q

What are the ADR of ACE-i?

A

Dry cough
hypotension
hyperkalaemia
AKI

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4
Q

What are the ADR of BB?

A 
hypotension
bradycardia
exacerbation of asthma
Fatigue
worsens ACUTE HF
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5
Q

What are the ADR of CCB?

A

Flushing
Hypotension
Peripheral oedema
bradycardia

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6
Q

What are the ADR of diuretics?

A 
hypotension
electrolyte abnormalities 
AKI
Gout
Spironolactone causes gynaecomastia
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7
Q

What are the ADR of LMWH?

A

Haemorrhage

herparin induced thrombocytopenia

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8
Q

What are the ADR of aspirin?

A

Haemorrhage
Peptic ulcer
gastritis
tinnitus in large doses

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9
Q

What are the ADR of digoxin?

A

N+V+D
blurred vision
drowsy/ confused
xanthopsia (halo vision)

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10
Q

What are the ADR of amiodarone?

A

Pulmonary fibrosis
Thyroid disease (hypo and hyper - as is related to iodine - amIODarone)
grey skin
corneal deposits

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11
Q

What are the ADR of lithium?

A

Fine tremor –> tiredness –> arrthymias, seizures, coma, renal failure, DI

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12
Q

What are the ADR of haloperidol?

A

dyskinesias (acute dystonia)

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13
Q

What are the ADR of steroids?

A 
STEROIDS: 
Stomach ulcer
Thin skin
edema
right and left HF
OP
Infection - esp candida
Diabetes
Cushings Syndrome
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14
Q

What are the ADR of NSAIDs?

A

Peptic ulcers
Renal failure
Asthma
Clotting abnormalities

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15
Q

What are the ADR of statins?

A

Myalgia

rhabdomyolysis

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16
Q

What is potassium’s effect on digoxin?

A

Digoxin competes with potassium at the myocyte Na+/K+ ATPase, limiting
Na+ influx. low K+ augments digoxin effect. High levels limit
the effect

17
Q

What drugs should you look out for when it comes to interactions?

A
  1. those with narrow theraputic index
  2. those that need careful titration or can cause ADR e.g. anti-htn and anti-DM drugs
  3. drugs that affect cytochrome P450 (PC BRAS and AODEVICES)

PSA (7 decks)

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