Chapter 8a Flashcards
What is the difference between obstructive and restrictive lung diseases?
Obstructive (airway): Normal Total Lung Capacity, Reduced Expiratory Flow Rate
Restrictive (parenchymal): Total Lung Capacity Reduced, Expiratory Flow Rate Normal
What are 3 examples of obstructive lung diseases?
- COPD
- Bronchiectasis
- Asthma
What are 3 examples of restrictive lung disease?
- Chest Wall Disorders
- Diffuse Parenchymal Lung Disease
- Lung Scarring
How to distinguish between obstructive and restrictive disease?
Spirometry. Measures lung volume and flow rate
Pathogenesis of obstructive lung disease?
Problem with ventilation, usually at level of small branches of bronchial tree
- exhalation affected more and requires effort
- wheeze heard (air forced through small bronchi)
What is the pathogenesis of obstructive sleep apnea?
Episodes of partial or complete closing of the upper airways during sleep.
due to jaw and tongue falling backwards and obstructing airway
What are 3 consequences of obstructive sleep apnea?
- Pt wakes repeatedly to gasp for air
- Hypoxemia
- Poor sleep
In which group of people is obstructive sleep apnea more common?
Men, Obese
What is the pathogenesis of asthma?
- Exposure to precipitating factors
- ‘atopic’ (foods, drugs, animal antigens etc)
- ‘non-atopic’: hypersensitive airways and irritants may trigger attack ie exercise, air pollution, smoke) - Previous sensitisation causes IgE mediated response causing activation of mast cells and direct stimulation of nerve receptors
- Mast cells release chemical mediators resulting in recruitment of eosinophils, bronchoconstriction, increase in vascular permeability, increase in mucus secretion
- Recruited eosinophils and T helper cells release further mediators which amplify and sustain inflammatory response
What is the consequence of repeated episodes of asthma?
Over-reactivity of airways & remodelling of airways
What is a condition of severe asthma?
Status Asthmaticus. Prolonged bronchospasm and mucus pluggingg results in respiratory failure
What are 5 structural changes seen in asthmatic patients?
- Hyperactivity and hypertorphy of smooth muscle of bronchus
- Hypersecretion of mucus
- Mucosal edema
- Infiltration of bronchial mucosa by eosinophils, mast cells, lymphoid cells and macrophages
- Deposition of collagen beneath bronchial epithelium in longstanding cases
In which patients are COPD seen in?
chronic smokers
What are two points that make COPD different from asthma?
- Airflow limitation is not fully reversible
- Disease is progressive
What is the progression of COPD?
stable for periods of time, but as normal lung function is lost, relatively mild concomitant illness (ie viral upper respiratory tract infection/ poor air quality). may cause sudden deterioration in symptoms and hospitalisation
What are 3 main underlying pathologies contributing to COPD?
- Emphysema (destruction of airspaces and loss of elastic recoil)
- Chronic Bronchitis (mucus hypersecretion and luminal narrowing of airways)
- Bronchiolitis (narrowing of small airways by inflammation and scarring)
*1. affects alveoli; 2. + 3. affects airways
*whilst emphysema and airways disease may exist individually, usually co-exist to differing degrees
What is the definition of emphysema?
Permanent dilation of airspaces distal to the terminal bronchiole with destruction of tissue in absence of scarring
Destruction of alveolar walls results in loss of elastic recoil in lungs and reduction in gas exchange capacity
What is the pathogenesis of emphysema?
Parenchymal destruction by extra-cellular proteases/elastases
- normally proteases secreted by inflammatory cells are inactivated by extracellular protease inhibitors in the lung (ie alpha-1-antitrypsin)
Smoking can inhibit these protease inhibitors, contain abundant free radicals which cause tissue damage, and that persistent irritation leads to increased inflammatory cells in the lung which themselves release mediators and enzymes
some pt have alpha-1-antitrypsin deficiency
these elastases then destory the alveolar wall causing emphysema
What is 1 key pathological sign in emphysema?
Bullae
What is chronic bronchitis?
Cough productive of sputum on most days for 3 months of year for 2 successive years
There is airway obstruction related to luminal narrowing and mucus plugging resulting in alveolar hypoventilation
What is bronchiolitis?
- Inflammation of airways <2mm in diameter
- Macrophages and lymphoid cells infiltrate the airway wall
- May progress and lead to scarring and narrowing of airways, contributing to functional airway obstruction
What are 3 risk factors for COPD?
- Smoking exposure
- Recurrent childhood infections
- Occupational exposure to dust
What 2 things cause exacerbations of COPD?
- Infection
- Poor air quality
How do COPD pts die?
- Respiratory Failure
- Secondary Right heart failure (cor pulmonale)
