Chapter 8, part 2

Question 1

What demographic is gout often seen in?

Answer 1

90% is men > age 30

Question 2

Where is the most common location of gout?

Answer 2

1st M-T

Question 3

Where are the other locations of gout?

Answer 3

Mid-foot

Ankle

Question 4

Characteristics of gout

Answer 4

Rapid onset
Acute
Severe
Tender
Inflamed joint
Chronically may have SQ urate deposits- tophi on extensor surfaces

Question 5

Dx of gout

Answer 5

Requires synovial fluid analysis (negatively birefringent crystals, needle shaped)

Question 6

Chronic tx of gout

Answer 6

Allopurinal (after acute phase) to lower uric acid levels; or colchicine (preventive)

Question 7

Risk factors of gout

Answer 7

Increased meat, seafood, beer consumption

Question 8

Acute tx of gout

Answer 8

NSAIDs
Indomethacin
Colchicine (caution in renal/hepatic dz)
Steroids

Question 9

Pseudogout- Calcium Pyrophosphat Deposition Disease: typical location

Answer 9

Typically knee, but can be wrist or ankle

Question 10

Characteristics of pseudogout

Answer 10

Acute onset
Swollen, warm, red joint
May have fatigue, fever; usually self-limited

Question 11

What is pseudogout associated with?

Answer 11

OA
Aging
Hypothyroidism
Ca metabolic disorders
Hyperparathyroidism
Hemochromatosis
Hypomagnesemia
Hypophosphatemia

Question 12

Dx of pseudogout

Answer 12

X-ray: calcification of cartilage (chondrocalcinosis)

Synovial crystals with positive birefringent

Question 13

Tx of pseudogout

Answer 13

NSAIDs
Colchicine
Steroids
Caution in renal/hepatic dz