Chapter 8: Gastrointestinal and Antiemetic Drugs Flashcards
Apomorphine
Opioid narcotic; stimulates dopamine receptors, causes emesis
How do opioids affect the CNS?
Suppress CNS function (causes sedation, causes cardiac and respiratory depressant)
Can apomorphine be reversed?
Yes, because it is an opioid. An opioid antagonist such as naloxone can be used.
What type of emetic is the best option for cats? Name some examples
Alpha 2 agonist drugs (xylazine and medetomidine/dexmedetomidine)
What is a con to using hydrogen peroxide as an emetic?
It is a gastric irritant and can cause gastric ulcers
What are the five categories of anti-emetics?
Phenothiazine tranquilizers, antihistamines, promotability drugs, serotonin antagonists, NK-1 receptor antagonists
What is the mode of action for phenothiazine tranquilizers? Examples?
Often used for motion sickness 1-Block dopamine receptors in the CRTZ and emetic center. 2-Antihistamine effect 3-Mild blockage of acetylcholine Examples: Acepromazine, Chlorpromazine
What are the side effects to using phenothiazine tranquilizers? Contraindications?
Side effects: decreased BP, excessive sedation and ataxia
Contraindications: hypotensive patients, use caution with boxers
True or False. Phenothiazine tranquilizers greatly decrease anxiety/fear
False
What is the antihistamine mode of action for anti-emetic function?
Decreases vestibular apparatus impulse to emetic center (disrupt the signals from the ears that send signals to the brain regarding balance) by blocking H1 receptors in CRTZ. Because dogs have more H1 receptors, they are more receptive to this tx.
How do prokinetic drugs work? What are some examples?
Blocks dopamine and serotonin receptors, helps promote peristalsis
Often used as an antiemetic for chemotherapy patients
Examples: metaclopramide, cisapride
What are some contraindications when using metoclopramide?
Cause cause sedation, don’t use with phenothiazine tranquilizers, sometimes can cause frenzied behavior in cats, do not use with obstructed patients
What type of anti-emetic drug is ondansetron? What is the mode of action?
Serotonin Antagonist; blocks serotonin receptors in CRTZ
Often used in parvovirus candidates, and post-chemo therapy
What is the trade name for maropitant citrate? What type of drug is it?
Cerenia; it is an NK-1 Antagonist
What is the mode of action of cerenia?
Prevents the binding of substance P and Neurological-1 kinin receptors in the emetic center (that leads to emesis)
Also blocks pain
What are the 4 types of anti-diarrheal drugs?
1-Opioid derivatives
2-Anticholinergics
3-Anti-inflammatories
4-Adsorbents and protectants
What is the mode of action of opioid derivatives? What are some examples?
Increased segmental contraction, decreased peristaltic contraction. Examples: loperamide (Imodium)-OTC; Diphenoxylate (Lomotil)-Controlled class V
Why are opioid derivatives generally avoided with cats?
Can cause potential CNS excitement
Why should opioid derivatives be avoided when a patient has a bacterial pathogen
Slows down peristalsis which gives the bacteria (like salmonella) a greater chance of getting into the body.
What is the mode of action for anticholinergic drugs as an anti-diarrheal? What is an example of an anticholinergic drug?
Blocks acetylcholine m1 receptor
Decreases parasympathetic GI tract stimulation (motility and secretion).
Decreases segmental and peristaltic contractions
Example: Atropine
Why is atropine (anticholinergic drug) often not used as an anti-diarrheal?
It can have parasympathetic blocking effects, and it increases the patient’s heart rate so it can be dangerous when used in patients with cardiac issues.