Chapter 8 Flashcards

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1
Q

What is the need for transport systems.

A

The metabolic demands of most animals are high so diffusion over long distances is not enough to supply demands.

SA:V ratio gets smaller as organisms get bigger.

Hormones and enzymes may be needed in one place but made in another.

Food is digested in one organ system, but needed to be transported to other cells.

Waste products if metabolism need to be removed.

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2
Q

What do all circulatory systems have?

A

They have a liquid transport medium that circulates around system.

Vessels that carry the transport medium.

Pumping mechanism to move fluid around system.

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3
Q

What circulatory system do mammals have?

A

They have a closed, double circulatory system.

The blood passes through the heart twice in each circuit.
There is one circuit which send blood to the lungs from the heart to pick up oxygen and unload carbon dioxide and then returns back to the heart.

Another circuit where blood flows through the heart and is pumped out to travel all around the body before returning to heart.

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4
Q

Why do mammals require a double circulatory system?

A

They require a double circulatory system to manage the pressure of blood flow.

The blood flows through the lungs at lower pressure. This prevents damage to the capillaries in the alveoli and also reduces speed at which the blood flows, enabling more time for gas exchange.

The oxygenated blood from the lungs then goes back through the heart to be pumped out at a higher pressure to the rest of the body. This is important to ensure that all the blood reaches all the respiring cells in the body.

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5
Q

What do arteries do and how are they adapted?

A

They carry blood away from the heart and into arterioles.

Their muscle layer are more thicker than veins so that constriction and dilation can occur to control volume of blood.

Their elastic layer is thicker than veins to help maintain blood pressure and the walls stretch and recoil in response to heart beat.

They have thick walls to help prevent the vessels bumping due to high pressure.

They have narrow lumens to transport blood at high pressure.

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6
Q

What do the capillaries do and how are they adapted?

A

Capillaries form capillary beds as exchange surfaces, which are many branched capillaries. They also connect the arterioles to the vein.

Capillaries have walls that are only a single cell thick because they exchange materials between blood and tissue.

They are also narrow to slow blood flow and for red blood cells to fit through and squashed against the walls, and this maximises diffusion.

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7
Q

What do veins do and how are they adapted for their function?

A

They carry blood back into the heart.

Veins have thin walls with wide lumens and valves because they transport blood at low pressure

Their muscle layer is thin so cannot control blood flow.

They have a thin elastic layer because the pressure is low.

The walls are the thin as pressure is low and this means the vessels are easily flattened which helps the flow of blood up to the heart.

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8
Q

What is diastole?

A

The heart relaxes

Atria and ventricles fill with blood

Volume and pressure of the blood in the heart builds as the heart fills, but pressure in atria is at a minimum.

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9
Q

What is systole?

A

Atria and ventricle contract.

Pressure inside heart increase and blood is forced out of the right side of the heart to the lungs.

Volume and pressure of blood in heart at low at end of systole, and blood pressure in arteries are at a maximum.

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10
Q

What is SAN?

A

It is a wave of electrical excitation begins in the pacemaker area called the SAN, causing atria to contract and so initiates heartbeat.

It initiates the electrical impulse to start atrial systole.

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11
Q

What is AVN?

A

Picks up impulse from SAN.

Delays signal

Allows atria to fully contract and completes blood flow into ventricle.

Stimulates the bundles of HIS. It is a conducting tissue made of fibres, which penetrate through the septum between the ventricles.

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12
Q

What is bundle of HIS?

A

Transports impulse from AVN to apex.

At apex, purkyne fibres spread out through the walls of ventricles on both sides.

Spread of excitation triggers contractions of the ventricles, starting at the apex.

Contractions at the apex allows more efficient emptying of the ventricles.

Spreads impulses along the ventricles

It makes sure atria have stopped contractions before the ventricles start.

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13
Q

What is tissue fluid?

A

The fluid where cells are soaked in to facilitate substance exchange between cells and blood.

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14
Q

What is oncotic pressure?

A

It is the tendency of water moving into blood by osmosis generated by plasma proteins. Leave through fenestrations in capillary walls.

Plasma proteins in blood cause a difference in water potential between the blood and the tissue fluid, therefore osmosis can occur.

Oncotic pressure describes how likely is the water going into blood due to presence of proteins.

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15
Q

What is hydrostatic pressure?

A

It is generated by heart contractions
Changes according to locations
Arterial- blood enters
Venous- blood leaves

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16
Q

What is blood?

A

55% of blood is plasma- a yellow liquid
45% is ethrocytes

The function of blood is transport co2 and o2, digested food, nitrogenous waste, platelets, cells and antibodies in immune response.

Maintains blood temperature

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17
Q

What is lymph?

A

5-10% of tissue fluid drains into lymphatic capillaries.

Lymph contains less oxygen and nutrients than tissue fluid, but more fatty acids which are absorbed from small intestine.

Lymph is moved along lymph vessels by contractions of surrounding muscle. Lymph vessels have valves which stop backflow.

Lymphocytes build up at lymph nodes, and produce antibodies.

Lymph re-enters blood.

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18
Q

What is myogenic?

A

Cardiac muscle- own rhythm at 60 bpm.

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19
Q

What do the cardiac muscle do?

A

Have thick muscular layer

Myogenic- contracts and relax without nerves or hormones

Never fatigues as long as it have a supply of oxygen

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20
Q

What are coronary arteries?

A

Supply cardiac muscle with oxygenated blood
These branch off from the aorta
If they become blocked cardiac muscle won’t receive oxygen, therefore will not be able to respire and cells will die.
Results in myocardial infarction

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21
Q

Atria

A

Muscular wall is thinner
Has elastic to allow stretching
Only moves blood down to ventricles so no pressure

22
Q

Ventricles

A

Much thicker walls
Need to contract with greater force to push blood at higher pressure.

23
Q

Right ventricle

A

Pumps blood to lungs
Lower pressure to prevent damage to capillaries in lungs and blood flows slowly to allow time for gas exchange.
Thin muscular walls to left ventricle

24
Q

Left ventricle

A

Pumps blood to body

Higher pressure to ensure blood reaches all cells in body

Thicker muscular walls to enable larger contraction of muscle to create higher pressure

25
Q

Vena cava

A

Carries deoxygenated blood from body into right atrium

26
Q

Pulmonary vein

A

Carries oxygenated blood from lungs to left atrium

27
Q

Pulmonary artery

A

Carries deoxygenated blood to lungs to become oxygenated

28
Q

Aorta

A

Carries oxygenated blood from left ventricle to rest of body.

29
Q

Semilunar valves

A

In aorta and pulmonary artery

30
Q

Atrioventricular valves

A

Between atria and ventricles

31
Q

Left and right valves

A

Bicuspid- left
Tricuspid-right

32
Q

Septum

A

Separates deoxygenated blood and oxygenated blood
Maintains high concentration of oxygen in oxygenated blood to maintain concentration gradient to enable diffusion at respiring cells.

33
Q

How does the cardiac cycle look like?

A

Look at image!

34
Q

What is happening in the orange line?

A

It is aortic pressure.
Rises when ventricles contract as blood is forced into aorta.
Then gradually falls.
Never below 12kPA- elasticity of its wall creates recoil action needed if blood is to be delivered to the tissues.
Recoil only produces a temporary rise in pressure at start if relaxation phase.

35
Q

What is happening in the blue line?

A

Ventricular pressure

Low at first but gradually increases as ventricles fill with blood as atria contract.

Left atrioventricular valves close and pressure rises dramatically as thick muscular walls of ventricle contract.

As it rises of that of aorta, blood is forced into aorta past semilunar valves.

Pressure falls as the ventricles empty and walls relax.

36
Q

What is happening in the yellow line?

A

Atrial pressure
Always low because thin walls of atrium cannot create much force
Highest when contracting but drops when left atrioventricular close and walls relax
The atria then fill with blood, which leads to gradual build up of pressure until a slight drop when left atrioventricular valves opens and some blood moves into ventricle.

37
Q

Partial pressure

A

A way of describing oxygen concentration around haemoglobin.

38
Q

Dissociation

A

The readiness of haemoglobin to let go of oxygen.

39
Q

Affinity

A

The attraction of haemoglobin to oxygen

40
Q

Association

A

The readiness of haemoglobin to take in oxygen.

41
Q

Percentage saturation

A

How full of oxygen the haemoglobin molecule is.

42
Q

What is haemoglobin?

A

Group of proteins found in different organisms.
A protein with a quaternary structure.
Transport oxygen.

43
Q

What happens in the dissociation curve?

A

At first, the partial pressure of oxygen is very low.

Therefore the percentage saturation is low this is because there are very few haemoglobin groups bound to oxygen, do haemoglobin does not carry much oxygen.

At higher po2, more groups are bound to oxygen making it easier for more oxygen to be picked up.

The haemoglobin becomes very saturated at very high po2 as all the haem groups become bound.

44
Q

What is fetal haemoglobin?

A

When a foetus is developing, it is completely dependent on its mother to supply oxygen.
Oxygenated blood from mother runs close to deoxygenated fetal blood in placenta.
If blood had same affinity for oxygen to mother, then little of no oxygen will be transferred to blood of foetus.
But it has higher affinity for oxygen, so it removes oxygen from maternal blood as they move past each other.

45
Q

What is the Bohr effect?

A

Bohr effect is when high co2 concentration causes oxyhemoglobin curve to shift to right.
Affinity of oxygen decreases because the acidic co2 changes shape of haemoglobin slightly.

46
Q

What happens at tissues?

A

Lower affinity of o2.
Release o2 more readily for aerobic respiration.
High partial pressure of co2

47
Q

What happens at lungs?

A

Hb have higher affinity for o2
Release o2 less readily
Low partial pressure of co2

48
Q

How is oxygen transported?

A

Erythrocytes (RBCs) carry oxygen in the blood.
They are a biconcave shape, so there is a greater SA:V for diffusion.

They have no nuclei, so space for oxygen is maximised.

They have prosthetic haem groups, which have a high affinity for oxygen and combine reversibly to oxygen to absorb it/release it.

When erythrocytes enter the lung capillaries, they are deoxygenated so there is a steep concentration gradient so the diffusion rate is high.
When oxygen diffuses into erythrocytes, it forms a compound called oxyhaemoglobin (as it binds with the haemoglobin). This also maintains a steep concentration gradient so diffusion rate into the cell remains high.

49
Q

How is co2 transported?

A

5% is carried dissolved in the plasma
10-20% is combined with amino groups in polypeptide chains of haemoglobin to form carbaminohaemoglobin.
75-85% is converted to hydrogen carbonate ions in cytoplasm of red blood cells

50
Q

What happens when co2 reacts with h2o?

A

Forms H2CO3 which is catalysed by carbonic anhydride ions.

This dissociates to hydrogen ions and hydrogen carbonate ions.

Hydrogen carbonate ions move out of erythrocytes into plasma by diffusion down a concentration gradient.

Negatively charged chloride ions move into erythrocytes which maintains electrical balance of cell. Called chloride shift.

H+ ions bind to haemoglobin to form haemoglobinic acid and it acts as a buffer and prevents change in pH.