Chapter 8 Flashcards
Information flow through the nervous system follows the basic pattern
of a reflex
timulus S sensor S input signal S integrating center S
output signal S target S response
CNS, which
is t
the integrating center for neural reflexes. CNS neurons integrate
information that arrives from the sensory division of the PNS and
determine whether a response is needed.
multipolar
ified by the number of processes
that originate from the cell body. The model neuron that is commonly used to teach how a neuron functions is multipolar, with many
dendrites and branched axons (Fig. 8.2e). Multipolar neurons in the
CNS look different from multipolar efferent neurons
Two factors influence the membrane potential:
The uneven distribution of ions across the cell membrane. Normally, sodium (Na+), chloride (Cl-), and calcium (Ca2+) are
more concentrated in the extracellular fluid than in the cytosol. Potassium (K+) is more concentrated in the cytosol than
in the extracellular fluid.
2. Differing membrane permeability to those ions. The resting cell membrane
is much more permeable to K+ than to Na+ or (Ca2+) This makes
K+ the major ion contributing to the resting membrane potential
However, an average value for the resting membrane potential of neurons
is -70 mV (inside the cell relative to outside), more positive than
predicted by the potassium equilibrium potential. This means that
other ions must be contributing to the membrane potential. Neurons
at rest are slightly permeable to Na+, and the leak of positive Na+ into
the cell makes the resting membrane potential slightly more positive
than it would be if
the cell were permeable only to K+.
The Goldman-Hodgkin-Katz (GHK)
equation calculates
s the membrane potential that results from the
contribution of all ions that can cross the membrane. The GHK
equation includes membrane permeability values because the permeability of an ion influences its contribution to the membrane
potential.
The resting membrane potential of living cells is determined
primarily by
the K+ concentration gradient and the cell’s resting
permeability to K+, Na+, and Cl-.
A change in either the K+ concentration gradient or ion permeabilities changes
the membrane
potential. If you know numerical values for ion concentrations and
permeabilities, you can use the GHK equation to calculate the new
membrane potential.
For example, at rest, the cell membrane of
a neuron is only slightly permeable to Na+. If the membrane
suddenly increases its Na+ permeability,
, Na+ enters the cell, moving down its electrochemical gradient
The addition of
positive Na+ to the intracellular fluid does what
depolarizes the cell membrane
and creates an electrical signal. (good graph on pg 272)
To appreciate how a tiny change can have a large effect, think
of getting one grain of beach sand into your eye.
There are so
many grains of sand on the beach that the loss of one grain is
not significant, just as the movement of one K+ across the cell
membrane does not significantly alter the concentration of K+.
However, the electrical signal created by moving a few K+ across
the membrane has a significant effect on the cell’s membrane
potential, just as getting that one grain of sand in your eye creates
significant discomfort.
The ease with which ions flow through a channel is called the
channel’s
conductance (G)
Channel conductance varies with
s with the gating state of the channel and with the channel protein isoform. Some ion channels, such as the K+ leak channels
that are the major determinant of resting membrane potential,
spend most of their time in an open state. Other channels have
gates that open or close in response to particular stimuli.
Most
gated channels fall into one of three categories [
Mechanically gated ion channels are found in sensory
neurons and open in response to physical forces such as pressure or stretch.
2. Chemically gated ion channels in most neurons respond
to a variety of ligands, such as extracellular neurotransmitters
and neuromodulators or intracellular signal molecules.
3. Voltage-gated ion channels respond to changes in the
cell’s membrane potential. Voltage-gated Na+ and K+ channels play an important role in the initiation and conduction
of electrical signals along the axon.
An inactivated channel returns
to its normal closed state shortly after
the membrane repolarizes.
The specific mechanisms underlying channel inactivation vary
with different channel types.
Many channels that open in response to depolarization close
only
when the cell repolarizes. The gating portion of the channel
protein has an electrical charge that moves the gate between open
and closed positions as membrane potential changes. This is like
a spring-loaded door: It opens when you push on it, then closes
when you release it.
The speed with which a gated channel opens and closes also
differs among different types of channels. Channel opening to
allow ion flow is called
d channel activation. For example, voltagegated Na+ channels and voltage-gated K+ channels of axons are
both activated by cell depolarization
The Na+ channels open
very rapidly, but… and what is the result of this
the K+ channels are slower to open. The result
is an initial flow of Na+ across the membrane, followed later by
K+ flow
Ohm’s law
Current flow, whether across a membrane or inside a cell,
obeys a rule known as Ohm’s law [p. A-00]. Ohm’s law says that
current flow (I) is directly proportional to the electrical potential difference (in volts, V) between two points and inversely proportional
to the resistance (R) of the system to current flow: I = V * 1/R
or I = V/R. In other words, as resistance R increases, current
flow I decreases. (You will encounter a variant of Ohm’s law when
you study fluid flow in the cardiovascular and respiratory systems.)
resistance
you study fluid flow in the cardiovascular and respiratory systems.)
Resistance in biological flow is the same as resistance in
everyday life: It is a force that opposes flow. Electricity is a form of
energy and, like other forms of energy, it dissipates as it encounters resistance. As an analogy, think of rolling a ball along the
floor. A ball rolled across a smooth wood floor encounters less
resistance than a ball rolled across a carpeted floor. If you throw
both balls with the same amount of energy, the ball that encounters less resistance retains energy longer and travels farther along
the floor