Chapter 68 Androgens

Question 1

What are androgens?

Answer 1

Hormones produced by the testes, ovaries, and adrenal cortex

Major androgen is testosterone

Question 2

What effects does testosterone have on sex characteristics in males?

Answer 2

Pubertal transformation and spermatogenesis

Question 3

What effects does testosterone have on sex characteristics in females?

Answer 3

Clitoral growth and pubic hair

Question 4

What are other systemic effects of testosterone?

Answer 4

Skeletal mm. growth, erythropoietin effects, (men have greater HCT than women)

Question 5

What is the clinical use of testosterone?

Answer 5

Male hypogonadism, replacement tx, delayed puberty, anemia, replacement in menopausal women (controversial)

Question 6

What are products/routes for Androgen replacement therapy in hypogonadal males? What class schedule are these medications?

Answer 6

Class III drugs

Route and brand name of meds:
Oral - Androxy
IM - Depo-Testosterone
Transdermal Patch/GelTopical - Androderm/Androgel/Axiron
Nasal Gel - Natesto
Implantable pellets - Testopel
Buccal system - Striant

Question 7

Androgen (anabolic steriod) abuse significant risks?

Answer 7

HTN, suppression of release of LH and FSH, testicular shrinkage, sterility, gynecomastia,
acne, reduction in HDL, and increase in LDL

Psychological effects: intensify aggression