Chapter 6: Genetic Stratagies in Therapheutics Flashcards
Give 6 examples of the Protein Products of Recombinant DNA Technology
Insulin, Growth factor, Epidermal growth factor(Burns, ulcers), Hepatitis B vaccine(Prevention of viral hepatitis), Erythropoietin(Anemia), Factor VII(Hemophilia)
Explain gene replacement therapy for cystic fibrosis.
Bacterial cloning of human therapeutic gene, cloned therapeutic transgene inserted into Adeno-assiciated virus. AAV containing therapeutic transgene nasally dripped into lung, which enters lung cell nucleus. Trerapeutic transgene corrects genetic defect.
What is Ex vivo gene replacement therapy, and tell me some disease using this cure
Ex vivo gene replacement therapy involes the genetic manipulation of a patient’s target cells outside the body. Modified cells are then reintroduced into the same patient. Ex. X-linked Severe Combinded Immunodeficiency.