Chapter 6 Cell Division Flashcards
What is the cell cycle
a order of events that take place in the cell,
resulting in the division of the cell and formation of two new genetically identical daughter cells.
Interphase
During interphase:
DNA is replicated and checked for errors in the nucleus
protein synthesis occurs in the cytoplasm
mitochondria grow and divide
chloroplasts grow and divide in plant and algal cells
metabolic processes of cells occur
Stages of Interphase:
G1 - the first growth phase - the cell increases in size, organelles are synthesised and produced.
S - synthesis phase: DNA is replicated in the nucleus
G2 - the second growth phase: the energy stores are increased and replicated DNA is checked for errors.
Checkpoints in the cell cycle
G1 checkpoint - at the end of G1 phase before S phase. Checks for: - cell size, nutrients, growth factors, DNA damage. if the cell satisfies the requirements of this checkpoint it continues to the S phase else it enters the G0 phase - resting state.
G2 checkpoint - at the end of G2 phase before mitosis. Checks for: - cell size, DNA replication, any DNA damage.
Spindle fibre checkpoint - at metaphase - checks all chromosomes are attached to spindles and have aligned.
The importance of mitosis
essential for growth and repair of tissues.
also necessary for asexual reproduction.
Bacteria do not have a nucleus and reproduce through other means - binary fission.
Chromosomes before Mitosis
the DNA is replicated during interphase. Each chromosome is converted into two identical DNA molecules called chromatids.
There is a replication from one chromatid per chromosome to two.
Prophase during Mitosis
Chromatin fibres begin to coil and condense.
Protein microtubules form spindle shaped structures linking the poles of the cells. The fibres are necessary to move the chromosomes into the correct position before division.
Two centrioles migrate to opposite poles of the cell.
The spindle fibres attach to specific areas on the centromere and start to move the chromosomes to the centre of the cell
By the end of prophase the nuclear envelope has dissappeared
Metaphase
Chromosomes are moved by spindle fibres to form a plane in the centre of the cell called the metaphase plate, and then they are held in position. The metaphase plate is at the equator.
Anaphase
The centromeres holding together the pairs of chromosomes in each chromosome divide during anaphase. THe chromatids are separated - pulled to opposite poles of the cell by the shortening spindle fibres.
The ‘V’ shape of the chormatids is as a result of them being dragged by their centromeres through the liquid cytosol
Telophase
In telophase the chromatids have reached their poles are now called chromosomes. The two new sets of chromosomes assemble at each pole and the nuclear envelope reforms around them. The chromosomes start to uncoild and the nucleolus is formed.
Then cytokinesis begins
Cytokinesis in Animal cells
a cleavage furrow forms arround the middle of the cell. The cell-surface membrane is pulled inwards by the cytoskeleton until it is close enough to fuse around the middle forming two cells.
Cytokinesis in Plant cells
Plant cells have cell walls so a cleavage furrow cannot form. Instead vesicles from the Golgi apparatus begin to assemble in the same place as where the metaphase plate was formed. The vesicles fuse with each other and the cell surface membrane, dividing the cells in two.
Prophase 1 - Meiosis 1
Chromosomes condense, the nuclear envelope disintergrates, the nucleolus disappears and spindle formation begins just like in prophase in mitosis.
Homologous chromosomes pair up, forming bivalents, when chromsomes entangle causing crossing over.
Metaphase 1 - Meiosis 1
Homologous pairs of chromosomes assemble along the metaphase plate.
Independent assortment occurs when the homologous pairs are orientated on the metaphase plate. The maternal and paternal chromosomes end up facing either pole leading to many combinations and genetic variation.
Anaphase 1 - Meiosis 1
homologous chromosomes are pulled to either poles.
sections of DNA in sister chromatids will cross over once they break apart after being entangled. This will form recombinant chromatids. Genentic variation rises.
Telophase 1 - Meiosis 1
chromosomes assemble at each pole and the nuclear membrane reforms. Chromosomes uncold. The cell undergoes cytokinesis and divides into two cells. The reduction of chromosome number from diploid to haploid is complete.