Chapter 6 Flashcards
Molecules evoke same response as neurotransmitter (agonist)
Qualifying condition
Assess post synaptic actions
Microiontophoresis
Measures effects on membrane potential
Microelectrode
Glutamate receptors
AMPA, NMDA, kainate
Muscarine concentration
Inocybe, clitocybe
Muscarinic receptor antagonist
Atropine, scopolamine
Identify natural receptors using radioactive ligands
Ligand-binding methods
Example of ligand binding methods
Opiate receptors
Drug used in opiate overdose treatment notably for heroin
Naloxone
Transmitter-gated ion channel receptors (ionotropic)
Nicotine content acetylcholine receptors
GABA-A receptors
G-protein-coupled receptors (metabotropic)
Muscarinic acetylcholine receptors
GABA-B receptors
Localize synthesis of protein or peptide to a cell (detect mRNA)
In Situ hybridization
Involved in movement, mood, attention, and visceral function
Catecholaminergic neurons
Precursor for dopamine, norepinephrine, and epinephrine
Tyrosine
_________ primary neurotransmitter of the reward pathway
Dopamine