Chapter 58 Flashcards
The inflammation of gastric mucosa or stomach lining. Can be scattered or localized; erosive or non erosive
Gastritis
GI disorders such as gastritis, peptic ulcer disease, and gastric cancer can all result in altered _______ and _______.
Digestion, nutrition
Pathologic changes of gastritis include ________ congestion, ______, acute __________ cell infiltration, and ____________ changes in the superficial epithelium of the stomach lining
vascular, edema, inflammatory, degenerative
Inflammation of the gastric mucosa or submucosa that occurs after exposure to local irritants or other causes.
Acute gastritis
If the stomach muscle is affected during acute gastritis, _______ may occur .
Hemorrhage
Appears as a patchy, diffuse inflammation of the mucosal lining of the stomach. Leads to thinning of the the stomach walls and lining and muscle atrophy.
Chronic gastritis
When body stores of vitamin B12 are depleted ___________ results
Pernicious anemia
The _____________________ is critical for absorption of vitamin B12
Intrinsic Factor
Three types of chronic gastritis
A, B, atrophic
Chronic gastritis is associated with an increased risk for _________
Gastric cancer
_________ chronic gastritis is associated with autoimmune cause.
Type A
________ gastritis is associated with genetic links and pernicious anemia.
Type A
The most common form of chronic gastritis is ________.
Type B
________ gastritis is associated with H. Pylori infection.
Type B
_____ gastritis is seen most often in older adults.
Atrophic
_______ gastritis is associated with toxic exposure in the workplace such as benzene, lead, or nickel as well as H. pylori and autoimmune factors.
Atrophic
Chronic gastritis is caused by local irritation including irritation from.... 1- alcohol 2- Smoking 3- Chrohn's disease 4- Saliva 5- Pyloric sphincter surgery 6- Milk ingestion 7-Uremia 8- Radiation
All but 4, 6
__________, _________, and ________ can help prevent gastritis.
Balanced diet
Regular exercise
Stress- reduction
Which of these foods should be limited to avoid gastritis?
- Fish
- Chocolate
- Mustard
- Ice cream
- Alcohol
- Spices
All but 1, 4
Excessive use of ______ should be avoided when trying to prevent gastritis.
NSAIDs
Which of these are signs and symptoms of Acute gastritis?
- Pernicious anemia
- Epigastric discomfort relieved by food
- Nausea
- Anorexia
- Cramping
- Hematemesis
3, 4, 5, 6
Which of these are symptoms of Acute gastritis?
- Rapid onset of gastric pain
- Gastric hemorrhage
- Diarrhea
- Intolerance of fatty/spicy foods
- Dyspepsia
- Abdominal tenderness and bloating
- Melena
1, 2, 5, 6, 7
Aspiring/NSAID related gastritis may result in _______.
Dyspepsia
Gastritis or food poisoning caused by endotoxins has an abrupt onset usually occurring within __ hours of indigestion of contaminated foods and may present with _________, which is life-threatening.
5, gastric hemorrhage
Which of these are symptoms of chronic gastritis?
- Pernicious anemia
- Vomiting
- Anorexia
- Rapid onset epigastric pain
- Upper abdominal discomfort
- Intolerance of fatty and spicy foods
1, 2, 3, 5, 6
Which of these are symptoms of chronic gastritis?
- Hematemesis
- Epigastric pain relieved by food
- Nausea
- Gastric hemorrhage
- Dyspepsia
- Bloating
2, 3
______ is the gold standard for diagnosis gastritis.
EGD (via an endoscope with biopsy)
A ____________ of the biopsy of specimens from the EGD of gastritis is performed to rule out gastric cancer.
Cytologic examination
Tissue samples can be taken from a patient with gastritis to detect H. pylori using ___________. This test is most reliable if patients stop taking _________ for at least a week before .
Rapid urease testing, antacids
Flare ups of acute or chronic gastritis can result in _____________________.
Fluid and electrolyte imbalances
The healing process for acute gastritis is ________ and usually occurs within _________.
Spontaneous, few days
Interventions for acute gastritis include:
- ________ for patients with fluid imbalances
- ____________ if bleeding is severe
- Surgery (partial gastrectomy, pyloroplasty, vagotomy) for patients with ________ or ________.
- fluid replacement
- blood transfusions
- major bleeding, ulceration
IN the acute phase of gastritis, the health care provider prescribes drugs that ______ and _______ acid secretions in order to ____________.
block, buffer, relieve pain
_______________ are used to block gastric secretions in patients with gastritis.
H2-receptor antagonists
_____________ are used as buffering agents in patients with gastritis
Antacids
Famotidine (Pepcid), nizatidine (Axid), and ranitidine (Zantac) are examples of….
H2-receptor antagonists
Maalox and Mylanta are examples of ….
Antacids
aluminum hydroxide combined with: magnesium hydroxide (Maalox) and simethicone and magnesium hydroxide (Mylanta
__________ are antisecretory agents
PPIs (Proton Pump Inhibitors)
Omeprazole (Prilosec), pantoprazole (Protonix), lansoprazole (Prevacid), rabeprazole (Aciphex), and esomeprazole (Nexium) are all…..
PPIs
_______, _______, and ______ are used to treat gastritis .
H2-receptor antagonists, Antacids, PPIs
_______ is used to suppress gastric acid secretion in patients with gastritis
PPIs
True of False: The patient taking PPIs for gastritis should also take OTC Pepcid AC
False- Do not take any additional OTC drugs.
_________ increase pH of gastric contents by deactivating pepsin.
Antacids
___________ decreases gastric acid secretions by blocking histamine receptors in the parietal cells
H2- antagonists
Antacids should be given…
1hr and 3hrs after meals and at bedtime
You should not give other drugs within ______ hours of antacids
1-2
When giving Maalox or Mylanta, you should assess the patients for history of _______ disease and ______ failure and observe for side effect of ______. Liquid preparations are preferred.
Renal, Heart, diarrhea
When giving Amphojel, you may give to patients with _____ failure. Observe for side effect of ______ and alternate with magnesium antacid if this occurs. Liquid preparation is preferred
Renal, constipation
H2 antagonists should be given….
At bedtime (single dose preferred)
IV _______ and _______ may be given to prevent surgical stress ulcers.
H2-receptor antagonists: rantidine, famotidine
Sucralfate (carafate) is a…. .
Mucosal barrier Fortifier
___________ binds with bile acids and pepsin to protect the stomach mucosa.
Mucosal Barrier Fortifiers (Carafate)
Sucralfate (carafate) should be given….
1hr before and 2hrs after meals and at bedtime
*Do not give within 30 minutes of other drugs and antacids
________ suppresses H1K-ATPase enzyme system of gastric secretion
PPIs
DO not give ______ or ______ IV with other drugs. (give with filter and a separate line)
(pantoprazole) Protonix, esomeprazole (Nexium)
PPIs should be given…..
At bedtime: omeprazole (Prilosec), lansoprazole (Prevacid)
After morning meal: rabeprazole (Aciphex)
1 hour before meals: esomeprazole (Nexium)
True or False: PPIs may be crushed to be put into tube feedings.
False. DO NOT CRUSH
_______ gastritis may require vitamin B12 for prevention or treatment of ____________.
Chronic, pernicious anemia
Drugs associated with gastric episodes and irritation are _________, _______, and ________.
Corticosteroids, erythromycin, NSAIDs
True or False: bell peppers and onions are foods that may irritate the gastric mucosa for patients with gastritis.
True
True or False: Patients with gastritis should eat a bland diet and smaller, more frequent meals
True
True or False: Reducing stress through various techniques is helpful in reducing anxiety, but has nothing to do with gastritis
False (they help gastritis)
A mucosal lesion of the stomach or duodenum
Peptic Ulcer
Results when mucosal defenses become impaired and no longer protect the epithelium from the effects of acid and pepsin.
Peptic ulcer disease
Three types of ulcers:
Gastric, Duodenal, Stress
Most gastric or duodenal ulcers are caused by _________
H. Pylori infection
Gastric ulcers may result from a dysfunction of the ______
pyloric sphincter
___________ is delayed in patients with gastric ulceration
Gastric emptying
True or False: Increased blood flow to gastric mucosa allows ulceration to occur.
False- Decreased blood flow.
Gastric ulcers are deep and penetrating and usually occur….
On the lesser curvature of the stomach near the pylorus
Duodenal ulcers are deep, sharply demarcated lesions that penetrate through the mucosa and submucosa int other muscle layer (Muscularis propria.) Most duodenal ulcers occur…
In the upper portion of the duodenum.
The main feature of a duodenal ulcer is…
High gastric acid secretion
In patient with duodenal ulcers, pH levels are _____ in the duodenum for long periods.
low
_____________ meals, ________, and ______ excitation stimulate acid secretion
High-protein, calcium, vagus nerve
Along with hypersecretion, ____________ of food from the stomach results in a large acid bolus to the duodenum.
rapid emptying
Acute gastric mucosal lesions occur after an acute medical crisis or trauma (such as head injury or sepsis)
Stress ulcers
_____ for major surgery may lead to stress ulcers.
NPO
Patients susceptible to stress ulcers are those who are critically ill including those who have _________ (Curling’s ulcer), _______ (ischemic ulcer), or _____________ (Cushing’s ulcer)
extensive burns, sepsis, increased intracranial pressure
___________ (caused by gastric erosion) is the main manifestation of acute stress ulcers
Bleeding
ischemia— erosions—- ulceration—- may progress to massive hemorrhage