Chapter 5 liver Flashcards
What are function of liver
1) Carbohydrate metabolism
2) Protein metabolism
3) Fat metabolism
4) Bilirubin conjugation and excretion
5) Metabolism of hormones
6) Metabolism and excretion of drugs and toxin
7) Storage
8) Kuppler cells
9) H+ ion homeostasis
Carbohydrate metabolism?
Glycogen synthesis and the breakdown of glycogen (gluconeogenesis)
Protein metabolism?
deamination of amino acids
Urea synthesis
Synthesis of plasma proteins (non-immunoglobulins)
Fat metabolisms
Uptake and synthesis of lipoproteins
Metabolism of hormones
Polypeptide hormones
25- hydroxylation of vit D
Storage
Stores glycogen, vitamin and iron
Kupler cells
Contributes to activities of the reticuloendothelial system
H+ ion homeostasis
decrease in ureagenesis and increased glutamine synthesis in acidosis
Jaundice
yellow pigmentation due to deposition of bilirubin. Bilirubin more than 50 micromol per L
Jaundice can be divided into
3
Prehepatic
Hepatic
Post hepatic
Pre hepatic
Liver is presented with high bilirubin amount, exceeds the conjugating mechanism
Hepatic jaundice
Abnormality is the liver itself
Post hepatic jaundice
Obstruction to the biliary system
Gilbert syndrome cause which jaundice
It is a genetic disorder whereby the liver cannot properly process bilirubin.
Hepatic (pre-conjugation failure)
Dubin Johnson cause which jaundice
Hepatic (Post-conjugation failure)
