CHAPTER 5 (Exam 2)

Question 0

Cancer related death is responsible for _______ of all deaths among children less than 15 years of age?

a) 1%
b) 10%
c) 20%
d) 30%

Answer 0

B) 10%

Question 1

Environmental exposures do not influence the development of sporadic cancers?

a) True
b) False

Answer 1

A) True

Question 2

Sporadic carcinomas of the breast and colon are considered to be ___________.

a) Autosomal dominant cancer syndromes
b) Autosomal recessive syndromes of defective DNA repair
c) Familial cancers of uncertain inheritance
d) Acquired preneoplastic syndromes

Answer 2

C) Familial cancers of uncertain inheritance

Question 3

Which of the following is least likely to be involved with oncogenesis?

a) Genes involved in DNA repair
b) Growth-promoting pronto-oncogenes
c) Genes that regulate noncoding DNA
d) Growth-Inhibiting tumor suppressor genes

Answer 3

C) Genes that regulate non-coding DNA ??

Question 4

Which of the following is the second most prevalent karyotypic abnormality in tumor cells

a) Insertions
b) Deletions
c) Balanced translocations
d) Gene locations

Answer 4

B) Chromosomal Deletions

Question 5

An abnormal number of chromosomes that is not a multiple of organism’s haploid is termed __________?

a) Metaplasia
b) Karyotype
c) Epigenetics
d) Aneuploidy

Answer 5

D) Aneuploidy

Question 6

Wich of the following involves DNA methylation and histone modifications to cause changes in gene expression?

a) Phenotypic dominance
b) Epigenetics
c) Genetic karyotyping
d) Alleles

Answer 6

B) Epigenetics

Question 7

Which type of mutation is highly associated with hematopoeitic malignancies?

a) Insertions
b) Deletions
c) Balanced translocations
d) Gene amplifications

Answer 7

C) Balanced translocations

Question 8

In sporadic cases of retinoblastoma both RB alleles are impacted via somatic mutation.

a) True
b) False

Answer 8

A) True

Question 9

Epigenetic refers to the reversible (heritable) changes in gene expression that are not the result of genetic mutation.

a) True
b) False

Answer 9

A) True

Question 10

Th RB gene is a tumor suppressor gene and is expressed in all cell types.

a) True
b) False

Answer 10

A) True

Question 11

Many oncogenic DNA viruses, like human papillomavirus, encode proteins that bind to the RB gene and render it nonfunctional.

a) True
b) False

Answer 11

A) True

Question 12

The TP53 gene is an example of a ___________?

a) Proto-pncogene
b) Oncogene
c) Tumor suppressor gene
d) Oncovirus

Answer 12

C) Tumor Suppressor Gene

Question 13

If DNA damage is detected, the products of the TP53 gene stimulate cellular arrest in which stage of the cell cycle?

a) G1
b) G2
c) S
d) M

Answer 13

A) Late in the G1 phase

Question 14

Which of the following is a common example of a virus that can nullify the protective function of the Tp53 gene?

a) Human Immunodeficiency Virus
b) Hepatitis B virus
c) Varicella Zoster
d) Rotavirus

Answer 14

B) Hepatitis B Virus (HBV)

Question 15

Many tumors metastasize to the organ that presents the first ___________ they encounter after entering circulation?

a) Region of skeletal muscle tissue
b) Parenchyma
c) Inflammatory reaction
d) Capillary bed

Answer 15

D) Capillary bed

Question 16

What is the “glue” that holds cells together, which must be inactivated to initiate migration of a tumor cell through the extracellular matrix?

a) G-Protein
b) E-Cadherin
c) TP53
d) Whey Proteins

Answer 16

B) E-Cadherin

Question 17

Once in circulation, aggregated tumor cells may be afforded protection from anti-tumor host cells…

a) True
b) False

Answer 17

A) True

Question 18

Patients with xeroderma pigmentosum have an inherited defect in which DNA repair system?

a) Mismatch repair
b) Nucleotide excision repair
c) Homologous recombination repair
d) Weinert-Marchiori repair system LoL

Answer 18

B) Nucleotide Excision Repair