chapter 5: cell recognition and the immune system Flashcards
What is an infection
an interaction between the pathogen and the bodies defence mechanisms
types of lymphocytes response
- cell mediated response involving T lymphocytes
- humoral response involving b lymphocytes
non specific response
immediate and same for all pathogens
specific response
slower and specific to each pathogen
non specific examples
- physical barriers
- phagocytes
specific response examples
- cell mediated response (t lymphocytes)
- humoral response (b lymphocytes )
how do lymphocytes recognise cell belonging to the body (fetus)
- in the fetus lymphocytes are colliding with other cells
2.infection in the fetus is rare - lymphocytes will only collide with the body own cells
4.lymphocytes with the complementary receptors to the bodies cell will be killed or suppressed - only lymphocytes that fight foreign material are left
how lymphocytes recognise cells belonging to the body (adult)
- lymphocytes produced in the bone marrow initially only encounter self antigens
- lymphocytes that show an immune response to the self antigens will undergo cell death (apoptosis)
- only lymphocytes that respond to foreign material are left
types of white blood cells
- phagocytes
- lymphocytes
phagocytes
ingest and destroy the pathogen by phagocytosis
lymphocytes
involved in immune response
phagocytes
large particles are engulfed by cells in the vesicles formed form the cell surface membrane
phagocytes (role)
carry out phagocytosis
phagocytosis process
1.chemical products of pathogens act as attractants for the phagocytes
2. phagocytes have receptors on their cell surface membrane that recognise and attach to chemicals on the surface of the pathogen
3. engulf the pathogen to form a vesicle (phagosome)
lysosomes fuse with the vesicle
lysosomes destroy bacteria by hydrolysis of cell wall
the initial response of the body
non- specific
immunity
the ability of organisms to resist infections by protecting against disease- causing microorganisms. involves the recognition of antigens
what is an antigen
any part of an organism that is recognised as non self. stimulates an innume resposne
the presence of a antigen…
triggers the production of an antibody as part of the bodies defence system
t lyphocyests can distuinsgust invader cells form normal cells v]becaue
- phagocytes present a pathogens antigen on its surface
- body cells invaded by viruses presented its antigen on its surface
- transplanted cells from the same species have different antigens
- cancer cells have different antigens
cells that present foreign antigens on their surface
antigen presenting cells