Chapter 5: Biopharmaceutical and Pharmacokinetic Considerations Flashcards

1
Q

result from the entrance of the drug into the circulatory system and transport to the cellular site of its action

A

systemic effects

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

oral route of administration: systemic effect or local effect

A

systemic effect

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

most natural, uncomplicated, convenient and safe means of administering drugs

A

oral route

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

disadvantages of oral route

A

slow drug response,
chance of irregular absorption of drugs,
destruction of certain drugs by the acid reaction of the stomach

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

rectal route of administration: systemic effect or local effect

A

both

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

solid bodies of various weights and shapes intended for introduction into a body orifice

A

suppository

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

route preferred for drugs destroyed or inactivated by the environments of the stomach and intestines

A

rectal route

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

route preferred when the patient is unconscious or incapable of swallowing

A

rectal route

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

disadvantages of rectal route of administration

A

incovenient,

offensive

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

parenteral route of administration: systemic effect or local effect

A

systemic effect

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

three primary routes of parenteral administration

A

subcutaneous,
intramuscular,
intravenous

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

route preferred for drugs destroyed or inactivated in the git or too poorly absorbed to provide satisfactory response

A

parenteral route

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

route preferred when rapid absorption is essential

A

parenteral route

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

route preferred in treating patients who are uncooperative, unconscious, or otherwise unable to accept oral medication

A

parenteral route

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

disadvantage of parenteral route administration

A

no retreat

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

entails injection through the skin into the loose subcutaneous tissue

A

subcutaneous injections

17
Q

example of drug administered by the subcutaneous route

A

insulin

18
Q

performed deep into the skeletal muscles

A

intramuscular

19
Q

specific parts of muscle for intramuscular injection

A

gluteal,

lumbar

20
Q

route preferred for drugs irritating to subcutaneous tissue

A

intramuscular injection

21
Q

an aqueous solution is injected directly into the vein

A

intravenous injection

22
Q

administered into the corium

A

intradermal injections

23
Q

common sites for injection include arm and back

A

intradermal injection

24
Q

administered topically or applied to the skin

A

epicutaneous route

25
Q

nitroglycerin

A

antianginal

26
Q

testosterone

A

male hormone

27
Q

oxybutynin

A

overactive bladder

28
Q

methylphenidate

A

adhd

29
Q

rivastigmine

A

dementia

30
Q

nicotine

A

smoking cessation

31
Q

estradiol

A

estrogenic hormone

32
Q

clonidine

A

antihypertensive

33
Q

scopolamine

A

antinausea,

anti-motion sickness

34
Q

usually viscud to prolong contact with affected area

A

ear preparations

35
Q

achieved by direct application of the drug to the desired site of action

A

local effects