Chapter 5 Flashcards
Health psychology
Concerned with effects of stress and other psychological factors in development and maintenance of physical problems. Subspecialty with behavioural medicine
Behavioural medicine approach
Concerned with psychological factors that may predispose individuals to medical problems
What is stress?
Psychological condition that results when we experience or perceive challenges to physical or emotional well being that exceed our coping resources and abilities. Is an interactive and dynamic construct because it reflects interaction between organism and environment
Stress vs stressors vs coping strategies
Stressors: external demands
Stress: effects stressors create within organism
Coping strategies: efforts to deal with stress
Good stress and bad stress
Both types of stress can tax persons resources. Bad stress (distress) typically has potential to do more damage
Stress and DSM
Stress is recognized in diagnostic formulations, notably in ptsd. Ptsd used to be classed as anxiety disorder, but DSM 5 created new class of disorders called trauma and stressors related disorders, now ptsd is classed there. This category also includes adjustment disorder and acute stress disorder. Disorders involve patterns of psychological and behavioural disturbances
Why do some people experience problems when under stress?
May be linked to coping skills and presence or absence of particular resources. Children are more sensitive to war and terrorism, adolescents with depressed parents are more sensitive to stressful events
Individual characteristics that improve persons ability to handle stress
Higher levels of optimism, greater psychological control or mastery, increased self esteem, better social support. Differences in coping styles may be linked to underlying genetic differences
Stress and genetics
Genetic makeup can render us more or less stress sensitive. Research determined that particular form of particular gene (5HTTLPR gene) was linked to how likely person was to become depressed when faced with stress (having 2 short forms of gene and experiencing 4 or more stressful life events, especially interpersonal events)
Cumulative stress
Amount of stress faced earlier in life may also make more sensitive to stress later in, showing it may be cumulative
Stress tolerance
Refers to persons ability to withstand stress without becoming seriously impaired
Stressful experiences as self perpetuating cycle
Stressful experiences may create self perpetuating cycle by changing how we think about things that happen to us. People with history of depression tend to experience negative events as more stressful than other people
Key factors involved in stressors (6)
- Severity ofstressor
- It’s chronicity
- It’s timing
- How closely it affects our own lives
- How expected it is
- How controllable it is
Which stressors are more stressful?
Stressors that involve important aspects of persons life; stressors that last a long time; encountering a number of stressors at same time; when someone is more immediately involved in traumatic situation; events that are unpredictable and unanticipated (study: patients who underwent major surgery were less anxious when they were given realistic expectations about outcomes); events that are uncontrollable
Crisis
Term used to refer to times when stressful situation threatens to exceed or exceeds adaptive capacities of person or group. Often especially stressful because stressors are so potent that coping techniques we typically use do not work
Stress vs crisis
Traumatic situation or crisis overwhelmed persons ability to cope, whereas stress does not necessarily overwhelm person
Social adjustment rating scale
Self report checklist of fairly common stressful life experiences to measure life stress. Limitations of check list method later led to development of interview based approaches
Life events and difficulties schedule (LEDS)
Interview based approach to measure life stress. Includes extensive manual that provides rule for rating both acute and chronic forms of stress. Allows raters to consider context in which life event occurs and take into account unique life circumstances (ex pregnancy in married woman vs teenager). Although more time consuming and costly than checklist, it’s also more reliable and preferred for research
Resilience
When, after experiencing potentially traumatic event, some people function well and experience very few symptoms. Resilience is not rare- it is most common reaction following loss or trauma
Why are some people more resilient than others?
No single factor predicts resilience, is linked to variety of different characteristics. Factors that increase resilience: Being male; being older; being well educated; having more economic resources; being a positive person ( being negative is associated with doing less well after traumatic event); people who are very self confident. When social class is controlled for, race and ethnicity are not predictive of reduced resilience.
Allostatic load
Biological cost of adapting to stress. When relaxed and not experiencing stress, allostatic load is low, when we are stressed and feeling pressured, it is higher. Stress has become key underlying theme in understanding of development and course of all physical illness
Stress And illness
Stress can exacerbate/aggravate symptoms in people with illness (MS, migraines, allergies, arthritis). Also increased susceptibility to catching a cold and increases risk of heart attack (ex death from coronary heart disease rise in days after major earthquake). Everyday stress (working, giving short speech) can also elevate risk for heart disease. Interesting to note that most heart attacks occur on Mondays in people who work
Stress response
When faced with threat of perceived stressor, body undergoes cascade of biological changes. There are 2 systems in stress response:
Sympathetic-adrenomedullary (SAM) system and
Hypothalamus-pituitary-adrenal system
Sympathetic-adrenomedullary (SAM) system
Response begins in hypothalamus, which stimulates sympathetic nervous system, which causes inner portion of adrenal glands (adrenal medulla) to secrete adrenaline and noradrenaline. These hormones cause increase in heart rate and cause body to metabolize glucose faster.
Hypothalamus-pituitary-adrenal (HPA) system
Hypothalamus releases hormone called corticotropin-releasing hormone (CRH) which stimulates pituitary gland. Pituitary secrets adrenocorticotropic hormone (ACTH) which induces adrenal cortex (outer portion of adrenal gland) to produce stress hormones glucocorticoids. (In humans, this is cortisol)
Cortisol
Prepares body for fight or flight and inhibits innate immune response (so bodies inflammatory response to injury is delayed). Escape has priority over healing, and tissue repair is secondary to staying alive.
Downside to cortisol
If not shut off, can damage brain cells, especially hippocampus. It may even stunt growth. When brain receptors detect cortisol, they send feedback message that is designed to dampen activity of glands involved in stress response. But if stressor remains, HPA axis stays active and cortisol release continues. If HPA axis is chronically active, this could be problematic
Psychneuroimmunology
Study of interactions between nervous system and immune system. Brain and immune system influences each other. Status of immune system also influences current mental states and behavioural dispositions by affecting blood levels of circulating neurochemicals, which modify brain states.
Immunosuppression
Can be caused by glucocorticoids because of stress. Longer term stress creates problems for immune system
Immune system
Protects body from viruses and bacteria. If it is too weak, it can’t function effectively and body succumbs to damage from imaging viruses and bacteria. If it is too strong and unselective, it can turn on body’s own healthy cells leading to autoimmune diseases
White blood cells
Leukocytes or lymphocytes. Produced in bone marrow and stored throughout body, are first line of defence.
Leukocytes
2 types: B-cell, and T-cells. When stimulated, b-cells and t-cells becomes activated and multiply rapidly, mounting various forms of counterattack
B-cells
Matures in bone marrow, produces specific antibodies that are designed to respond to specific antigens. When recognizes antigen, it begins to divide and produce antibodies that circulate in blood. This is facilitated by cytokines released by t-cells. Production of antibodies takes 5 days or more. But response of immune system will be much more rapid id antigen appears in future because immune system had memory of invader
Antigens
Foreign bodies such as viruses and bacteria and internal invaders such as tumour and cancer.
T-cells
Matures in thymus, which is important endocrine gland. Circulate throughout body and lymph systems in inactive form. Has receptors on surface that recognize one specific type of antigen, but are unable to recognize antigens by themselves. Become activated when macrophages detect antigens abs start to engulf and digest them. To activate t-cells, macrophages release chemical called interleukin-1
Cytokines
Small protein molecules, important component of immune system. Serve as chemical messengers and allow immune cells to communicate with each other. In addition to communicating with immune system, also influences the brain. Brain and body work together to coordinate response to sickness. When unwell, feel tired and have little appetite. This is result of effects of cytokines. Causing us to rest into better.
Influences between brain and immune system
Brain is influenced by products of immune system. Brain can also influence immune processes. Chronic problems at level of immune system may lead to behavioural changes or psychiatric problems
Categories of cytokines
Proinflammatory cytokines and anti inflammatory cytokines
Proinflammatory cytokines
Ex interleukin-1, tumour necrosis factor. Help us deal with challenges to immune system by augmenting immune response. Process is disrupted under conditions of stress, which effects healing of wounds (cytokines are still present, but at much lower levels)
Anti inflammatory cytokines
Decrease or dampen response that immune system makes. Sometimes accomplish this by blocking synthesis of other cytokines
Chronic stress and inflammation
Inflammation is increased in people who are under prolonged stress because long term stress seems to interfere with body’s ability to turn off cytokine production
Cytokines and cortisol
Cortisol is supposed to regulate (turn off) cytokine production. Cytokine production sets of negative feedback loop that is designed to prevent an excessive or exaggerated immune or inflammatory response. Chronic stress seems to impair body’s ability to respond to signals that will terminate immune system reactivity, resulting in inflammation
Why is chronic inflammation bad?
Chronic inflation is a risk factor for: cardiovascular disease, type 2 diabetes, asthma, osteoporosis, rheumatoid arthritis etc. Reason why doctors test for presence of C-reactive protein, a molecule produced by liver in response to stress hormone, when assessing persons risk for heart disease
Stress in Alzheimer’s caregiver’s vs relocation
Correlational study found that there was higher stress in women who were caring for Alzheimer’s patients than in women anticipating stress of relocation. Age was no factor in this study
Stress and discrimination
Discrimination is a form of chronic stress, there are elevated levels of CRP in African Americans
Correlational research
Researchers observe or assesses characteristics of different groups, learning much about them without manipulating conditions to which they are exposed
Traumatic stressors experienced during childhood seem to increase risk of…
Premature death in later life. In a study, People who had reported 6+ adverse events during childhood died much earlier than would be expected. Top two leading causes of death were heart disease/stroke and cancer
Why might stress in childhood cause premature death?
Early life stress may have biological consequences that advance aging, making more likely that people die earlier from kinds of diseases that are associated with increased age. Telomeres might be part of answer
Telomeres
Protective end parts of chromosomes. Shorten with age. Stress shortens length of telomeres. Stress hormone cortisol can reduce activity of telomerase, enzyme that maintains telomeres (also learning that drinking too much sugar sweetened soda might shorten telomeres). Pessimism accelerates rate of telomere shortening. Meditation may promote telomerase activity. Exercise seems to act as buffer against bad effects
Personality: type A behaviour pattern
Characterized by excessive competitive drive, extreme commitment to work, impatience and time urgency, and hostility. Type A personality associated with increased risk for coronary artery disease and heart attack. Hostility component of type A personality that is most closely related with coronary artery deterioration
Type D personality type
“Distressed”. Tendency to experience negative emotions and also feel insecure and anxious. Men with CHD who scored high on measures of chronic emotional distress were more likely to have fatal and non fatal heart attacks. People with higher scores of negative affective component of type D personality are at increased risk of having more problems after cardiac surgery
CHD
Coronary heart disease
Depression and immune function
Depression is associated with decreased immune function , partially independent of specific situations or events that provoked depression, ie state of being depressed adds something beyond negative effects of stressors precipitating depressed mood.
Depression and heart disease
Depression also factor in heart disease. Depression is more common in people with heart disease than in people with other serious diseases. Also heart attack patients with high levels of depressive symptoms after heart attack are more likely to die within 5 years. Anhedonia may be predictive of increased mortality after heart attack
Anhedonia
Symptom of depression characterized by profound loss of interest or pleasure
Depression appears to be a __________ for __________ CHD
Risk factor
Developing
Link between depression and future heart problems remained even when other potential confounding variables such as lifestyle were taken into account