Chapter 47- Drugs for hypertension Flashcards
What are 4 drugs classes that suppress RAAS
-ACE inhibitors
-ARBs
- Direct renin inhibitors
-aldosterone antagonists
what are 2 examples of centrally acting alpha 2 agonists?
-clonidine
-methyldopa
reserpine belongs in which drug class?
Adrenergic neuron blockers
What should you do first before initiating drug therapy for antihypertensives?
Lifestyle changes
Drug therapy should begin with how many agents?
1
What do you do if the first drug is being tolerated but inadequate?
Add another drug
If the first drug is not well-tolerated what should you do?
Substitute
What are 2 reasons why initial drug failed to be effective?
-dose too low
-noncompliance
If you are using more than 1 drug, the drugs must do what?
Come from different classes with different MOAs
What are 3 benefits of multidrug therapy?
-controlling BP at various sites can increase success
-each drug can be administered in lower doses
-one drug can offset the adverse effects of the other
What dosage should every drug begin at?
lowest dose possible and then gradually increased as necessary
High doses carry a greater risk of what?
ADRs
if your BP is slowly reduced, the baroreceptors can gradually reset to the newer lower pressure which causes what?
less resistance
When should attempts be made to reduce dosages and number of drugs while continuing lifestyle modifications?
Once BP has been controlled for at least 1 year
DBP >120 mmHg indicates what?
Hypertensive crisis
