Chapter 4 (module 2) terms

Question 1

pharmacogenetics

Answer 1

the study of the variability in drug response due to heredity

Question 2

allele

Answer 2

one of two or more versions of a gene; an individual inherits two alleles for each gene (ex. Hh)

Question 3

gene

Answer 3

region of DNA containing genetic info

Question 4

genome

Answer 4

the totality of genetics info found in an organism’s DNA/RNA

Question 5

genomics

Answer 5

the study of the combination of the environment (personal factors + genetic info)

Question 6

genotype

Answer 6

an individual’s collection of genes

Question 7

phenotype

Answer 7

visible characteristics of a genotype

Question 8

polymorphisms

Answer 8

natural variations in a gene, DNA sequence, or chromosome that have NO adverse effects on the individual

Question 9

extensive metabolizers

Answer 9

have an ordinary response to drugs

Question 10

intermediate metabolizers

Answer 10

dec in drug metabolism; inc concentration of the parent drug (possible dec in responsiveness)

Question 11

poor metabolizers

Answer 11

dec in drug metabolism; higher levels of patent drug but with little therapeutic benefit (inc risk for adverse drug response)

Question 12

ultrarapid metabolizers

Answer 12

inc drug metabolism; results in possible dec in effectiveness