Chapter 4

Question 1

Filgrastim is produced in this organism.

Answer 1

E. coli

Question 2

Filgrastim is identical to native human G-CSF except for the addition of this.

Answer 2

An amino-terminal methionine

Question 3

This is the full name for pegfilgrastim.

Answer 3

Pegylated methionyl G-CSF

Question 4

Pegylation reduces the ______ clearance of G-CSF and prolongs its circulation and the duration of its effects.

Answer 4

Renal