Chapter 32 Pharm

Question 1

Diphenydramine

Answer 1

Max of 400 mg day

Acts within 15 to 60 minutes lasts up to 4 to 6 h

Question 2

Diphenydramine Works by

Answer 2

Occupying the same receptor sites as histamine which prevents histamine from acting on target tissues.
• Drugs are effective in inhibiting vascular permeability, edema formation, bronchoconstriction, pruritis
Uses

Question 3

Diphenydramine Uses

Answer 3

Hypersensitivity reactions (Allergic rhinits, conjuctivitis, dermatitis)
• Motion sickness
• Insomnia
• Parkinsonism

Question 4

Diphenydramine Assess for:

Answer 4

CNS depression (Drowsiness, sedation)
• CNS stimulation (Anxiety, agitation)
• Anticholinergic effects (Dry mouth, urinary retention, constipation, blurred vision)

Question 5

Diphenydramine

Contraindications

Answer 5

Pregnancy
• Narrow angle glaucoma
• Prostatic hypertrophy
• Bladder neck obstruction

Question 6

Fexofenadine

Answer 6

Peak action 2.5 hrs lasting 12- 24 h

max dose 180 mg

Question 7

Fexofenadine Works by

Answer 7

Competiting with histamine for binding sites preventing the activation of cells by histamine. Thus preventing allergy symptoms from occuring. Bc the drug does not cross the blood brain barrier it does not cause drowsiness.

Question 8

Fexofenadine Use

Answer 8

Seasonal allergic Rhinitis

• Uritcaria

Question 9

Fexofenadine Assess for

Answer 9

Headache
• Nausea
• Vomiting
• Dysmenorrhea • Fatigue
Only with water (Fruit juice may decrease absorption
Shake oral suspensions completely before administration