Chapter 32 Hypertension Flashcards
Which race has the highest prevalence of hypertension in the world?
African Americans
have a higher incidence of hypertension among women than among men
Have more nocturnal non-dipping BP
results in more severe end-organ damage
Which race is least likely to receive hypertension treatment?
Mexican-Americans
Low rate of controlled BP
Low levels of awareness
Which sex is more likely to develop hypertension?
Men
BUT
Women on an oral contraceptive are 3x more likely to develop hypertension
How do you calculate Blood Pressure?
Cardiac Output x Systemic Vascular resistance = BP
What two body systems affect cardiac output?
Cardiac (Heart rate, contractility, conductivity)
Renal Fluid Volume Control (RAA system, natriuretic peptides)
What 3 body systems affect vascular resistance
Sympathetic Nervous System (Alpha 1 and 2 that causes vasodilation and Beta 2 that causes vasodilation) Neurohormonal (vasoconstrictors like angiotensin and norepinephrine) Local regulation (Vaso- Dilators/constrictors
What type of specialized cells in the carotid arteries and arch of aorta sense changes in BP and transmit this info to the brain
Barocreceptors (pressure receptors)
What effect does Alpha 1 have on the body?
Vasoconstriction increased contractility (positive ionotropic)
What effect does Alpha 2 have on the body
Inhibits norepinephrine release
vasoconstriction
What effect does Beta 1 have on the body
Causes a positive
Inotropic effect (contractility)
Chronotropic (heart rate)
dromotropic effect (conduction)
What is a positive and negative
1) inotropic effect
2) chronotropic effect
Dromotropic effect
1) increase or decrease in heart contractility
2) increase or decrease in heart rate
3) increase or decrease in heart conduction
What effect does Beta 2 have on the body
Vasodilation
What effect does dopamine receptors have on the body
Vasodilation
How does the renal system contribute to hypertension?
The kidneys regulate sodium and ECF volume, which dictates total fluid volume of the body
It also regulates the renin-angiotensin-aldosterone system.
Overall the kidneys regulate the amount of sodium and fluid in the body
What is are the different stages of hypertension
Normal BP: 100-120 /60-80
Pre-hypertensive: 120-139/ 80-90
Hypertensive Stage 1: 140-159/90-100
Hypertensive Stage 2: >160/>100
What is Isolated Systolic Hypertension (ISH)
An average systolic BP of 140 or greater with an average diastolic BP under 90
What is Primary Hypertension and what is the patients treatment goal?
Hypertension without an identified cause (it is idiopathic)
There are contributing factors though, such as:
SNS activity, hypernatremic, greater than ideal body weight, tobacco use, too much alcohol
Usually treated by trying to lower the BP by weight loss, lower sodium intake, or antihypertensive meds
What is Secondary Hypertension and what is the patients treatment goal?
Elevated BP with a specific cause such as cirrhosis, endocrine disorders, renal disease, NSAIDS, Oral contraceptives, corticosteroids
Treatment at removing the underlying cause
What role does the SNS have on BP
Increases HR and hear contractility
controls vasoconstriction and renin release
What are some severe symptoms of hypertension?
Fatigue, dizziness, palpitations, angina, dyspnea
What is the most common complication of hypertension?
Target organ disease
These include: CAD, Left ventricular hypertrophy, Heart failure, atherosclerosis, nephrosclerosis
How does hypertension affect the kidneys?
It causes Ischemia that leads to the narrowing of the renal blood vessels. This causes atrophy of the tubules and the eventual death of the nephrons
What labs are analyzed to see if renal disease is occurring?
Albuminuria, proteinuria, elevated serum creatinine and BUN
Is the retina important with hypertension?
Yes, it can provide important information about the severity and duration of hypertension
The damage can provide information that can help see if damage is occurring in the heart, brain, and kidneys.
What is the overall goal of treatment for a patient who has hypertension
Lower their BP, reduce their cardiovascular risk factors and their risk of target organ disease
What is the purpose of an electrocardiogram?
It provides baseline information about heart status
It can identify LVH (if suspected though an echocardiography is performed), Cardiac ischemia, previous MI