Chapter 3 Pharmacogenetics and Pharmacogenomics

Question 1

Poor metabolisers of isoniazid have defective:

Answer 1

N-acetyltransferase

Question 2

An ultra-rapid metaboliser of codeine would require:

Answer 2

a decrease in drug dose to ensure toxic effects do not occur.

Question 3

In general, a poor metaboliser would require:

Answer 3

a decrease in drug dose to ensure toxic effects do not

occur.

Question 4

Trastuzumab

Answer 4

to people that overexpress HER2 protein

HER2-positive breast cancer is a breast cancer that tests positive for a protein called human epidermal growth factor receptor 2

Question 5

State whether the following statement is true or false:

Differences in medication response between individuals is due solely to the genetic differences between people:

Answer 5

False

Question 6

Testing for the HLAB*5701 variant is performed in a(n):

Answer 6

individual with HIV

Question 7

Pharmacogenetics is the study of:

Answer 7

genetic factors and their influence on pharmacological response.

Question 8

Genetic polymorphisms of the TPMT gene will lead to altered TPMT activity and this needs to be measured before a specific medication is administered. The name of the medication is:

Answer 8

6-mercaptOPURine

Question 9

State whether the following statement is true of false:

The highest number of genetic variations associated with diffrences in medication response are attributed to enzymes involved in the metabolism of medications:

Answer 9

True

Question 10

State whether the following statement is true or false:

The inter-individual ariation in pharmacological response can be attributed to environmental, genetic and personal factors.

Answer 10

True