Chapter 3 (from the slides) Flashcards
What is the neuraxis?
- The invisible line splitting the body
- Anatomical directions are relative to the neuraxis
What is Rostral (anterior)?
- toward the head
What is Caudal (posterior)
- toward the head
- going down the spine toward the feet
What is Ventral?
- inferior
- toward the belly
What is dorsal?
- superior
- toward the back (top of the head)
What is ipsilateral?
- same side of the brain (hemisphere)
what is contralateral?
- opposite side of the brain (hemisphere)
What is the sagittal section?
- straight through and dividing the brain into two hemispheres through the corpus callosum
What is the coronal/frontal section?
- also known as transverse
- transverse cut through the brain
- cut from front to back
What is the horizontal section?
- also known as axial
- parallel to the ground
- cuts from top to bottom
How do you interpret an x-ray of the brain? (coronal cut)
- imagine that the patient is standing in front of you
- Your right will be the patient’s left. Your left will be the patient’s right.
What is the central nervous system?
- One of the two nervous systems
- comprised of the brain and spinal cord
- the spinal cord is a conduit for information to and from the brain
What is the peripheral nervous system?
- comprised of the cranial/spinal nerves and peripheral ganglia
Efferent messaging
- PNS carry information from the brain to the target organs and muscles
Afferent messaging
- The nerves carry sensory information from the muscles and target organs to the brain.
What are the brain and spinal cord protected by?
- the meninges
- contains the three layers that protects the brain
Dura Mater
- outermost and thick layer of the meninges
Arachnoid
- middle layer of the meninges
- overlies the arachnoid space
- CSF in arachnoid layer
Pia Mater
- inner most layer
- overlies every detail of the outer brain
- blood vessels run through the pia matter
What is meningitis?
- Infecting in the layer covering the brain
What is CSF
- cerebrospinal fluid
- brain sits in a pool of this and reduces its weight from 1400 g to 800 g
Where is the CSF contained?
- contained within the 4 ventricles in the brain
Where is the CSF produced?
- the choroid plexus of each ventricle
What occurs when the ventricles expand?
- when they get enlarged, disease can occur. Typically occurs with alcoholism or neurodegenerative diseases
Names of the ventricles
- lateral ventricles
- 3rd ventricle
- 4th ventricle
True or False: CSF is produced continuously
True
What occurs when CSF doesn’t drain properly?
- damage to the brain can occur.
- Hydrocephalus (water in the head) can occur
How is CSF produced?
- Created in the choroid pelus of the lateral ventricle s and then enters the the 3rd ventricle and then enters the 4th ventricle through the cerebral aqueduct
What are the arachnoid granules?
- granules that remove the CSF that flows around the brain
How is the CNS developed?
- Begins in the embryonic life as a hollow tube
- Maintains its basic shape even after fully developed
- The Tube is then created
- Elongates
- Forms pockets and folds
- Thickens until the brain reaches its final form
More about the CNS development
- created 28 days after conception
- the Forebrain, midbrain, and hindbrain are created in later development
- As it developms, the telencephalon, diencephalon, and myelencephalon are created
Which ventricles are associated with the CNS developent?
- Lateral Ventricles/forbrain = telencephalon
- Third Ventricle = midbrain
- 4th ventricle = hindbrain
What are the anatomical subdivisions of the forebrain?
- Major division: forebrain
- Ventricle: lateral and third ventricles
- subdivisions: telencephalon, diencephalon
Principle structures: cerebral cortex, basal ganglia, limbic system, thalamus, hypothalamus
What are the anatomical subdivisions of the midbrain?
- Major: midbrain
- Ventricle: cerebral aqueduct
- Subdivision: mesencephalon
- principle structures: tectum and tegmentum
What are the anatomical subdivisions of the hindbrain?
- Major: hindbrain
- Ventricle: fourth
- subdivison: metencephelon
and myelencephalon - principle structures: cerebellum, pons, medulla oblongata
How does the cortex develop?
- The cortex develops from the inside out. Main development stages: -progenitor cells (R) form the VZ (ventricular zone), and then expand into the SVZ (subventricular zone) by symmetric division; -progenitor cells initiate asymmetric division (one progenitor and one brain cell); -radial glia (scaffolding) stretch toward, and attach to the pia matter; -cortical layers form one by one with neurons migrating upwards
What is axonal growth?
- once the neurons are in their respective cortical layers, they grow axons and ATTEMPT to find space on adjacent neurons for synaptic connections
- about 50% of neurons vails to find postsynaptic “vacancies”. These neurons die by apotosis (programmed cell death)