Chapter 3 exam 1

Question 1

What are the two examples of TLR?

Answer 1

TLR4 and LPS

Question 2

Endosome

Answer 2

nucleic acids

Question 3

What is NFkB inhibited by?

Answer 3

IkB

Question 4

What protein removes IkB

Answer 4

Ikk

Question 5

What do NOD-like proteins do?

Answer 5

Monitor the cytoplasm for bacterial components

Question 6

What does Caspase 1 do?

Answer 6

Preparation for IL-1beta

Question 7

Where are macrophages located in the body?

Answer 7

In the tissue (long lived)

Question 8

Where are Neutrophils located in the body?

Answer 8

In the blood (short lived)

Question 9

What are Chemokines?

Answer 9

Chemoattractant cytokines

Question 10

What is CXCL8?

Answer 10

A chemokine secreted by pathogen (activated macrophages)

Question 11

What do Endothelial cells do?

Answer 11

Inducibly express adhesins

Question 12

What do Neutrophils do?

Answer 12

Constitutively express adhesins

Question 13

What do Extravasate’s do?

Answer 13

Cross basement membrane to inflamed tissue

Question 14

What are the three main granuals and lysosomes?

Answer 14

Primary (azurophilic) -> myeloperoxides
Secondary (specific) -> lactoferrin
Tertiary (gelatinase) -> gelatinase

Question 15

What do lysosomes contain?

Answer 15

Acid hydrolases

Question 16

What is a Respiratory burst?

Answer 16

It forms radicals and increases pH

Question 17

What are Endogenous Pyrogens and what are the three we need to know?

Answer 17

They cause a fever. IL-1, IL-6, TNF

Question 18

What does IL-6 do?

Answer 18

Tells the liver to activate the acute phase response

Question 19

What is Lectin?

Answer 19

Something that binds to a carbohydrate

Question 20

What do C1s subunits cleave?

Answer 20

C4

Question 21

What do RLR receptors sense?

Answer 21

Uncapped RNA (viruses)

Question 22

What are the three Transcription factors?

Answer 22

IRF3, NFkB, AP-1

Question 23

What are the two natural killer cells?

Answer 23

CD56, CD3