Chapter 3: 2nd PPTs

Question 1

The extent or fraction of drug absorbed upon extravascular administration in comparison to the dose size administered.

Answer 1

ABSOLUTE BIOAVAILABILITY

Question 2

The process of uptake of the compound from the site of administration into the systemic circulation. A prerequisite for absorption is that the drug be in aqueous solution. The only relatively rare exception is absorption by pinocytosis.

Answer 2

ABSORPTION OF DRUGS

Question 3

The increase of drug concentration in blood and tissue upon multiple dosing until steady state is reached.

Answer 3

ACCUMULATION

Question 4

The ration of the concentrations at equilibrium between a lipid phase and an aqueous phase. The apparent partition coefficient is uncorrected for dissociation or association in either phase.

Answer 4

APPARENT PARTITION COEFFICIENT

Question 5

The integral if drug blood level over time from zero to infinity, and is a measure of quantity of drug absorbed and in the body.

Answer 5

AREA UNDER THE CURVE

Question 6

The relative amount of drug from an administered dosage form which enters the systemic circulation and the rate at which the drug appears in the blood stream.

Answer 6

BIOAVAILABILITY

Question 7

A drug product is achieved if its extent and rate of absorption are not statistically significantly different from those of the standard when administered at the same molar dose.

Answer 7

BIOEQUIVALENCE

Question 8

The physical and chemical properties of the drug substance, the dosage from, and the body and the biological effectiveness of a drug upon administration.

Answer 8

BIOPHARMACEUTICS

Question 9

The actual site of action of drugs in the body.

Answer 9

BIOPHASE