Chapter 3 Flashcards
Which 2 parts of the neuron are most involved in delivery and reception of an electrical transmission?
Dendrite and Axon terminal
What would a result in demyelination of the axon be?
A slow down in electrical transmission as myelin sheath speeds up transmission
What is the purpose of the Nodes of Ranvier?
Momentarily slows down the transmission of an electrical impulse
What type of cells form the myelin sheath?
Glial cells
What other important roles do glial cells play in our nervous system?
They guide new neurons into place, nourish the neurons, detoxify them, and modulate communication between them
What is the purpose of the blood brain barrier and what forms it?
Glial cells form the BBB and its purpose is to prevent the entrance of foreign substances from the blood into the brain
If a graded potential occurs on a neuron, what does this mean?
It means that the neuron does not fire as it does not meet the threshold voltage of -55mV
What “state” is the neuron in when it is at rest?
Polarized state
During depolarization, what occurs?
Sodium flows into the neuron until +40mV is attained
What is it called when potassium ions flow out of the neuron to restore the resting potential of the membrane?
Repolarization
What implications can be drawn from the absolute refractory period?
It implies that there is a limit in the number of action potentials that occur for a neuron
Why is the resting potential of a neuron -70mV?
Due to the uneven distribution of ions as there are more positive sodium ions out than there are positive potassium ions in
Even if a single graded potential is not enough to cause an action potential, why is it possible for graded potentials to cause a neuron to fire?
Since neurons are connected, various graded potentials can be summed so the threshold is met to allow the neuron to fire.
What is the all or none law?
States that the minimum threshold of -55mV must be met in order for the neuron to fire
In chemical transmission, the axon terminal and dendrite of two separate neurons are related by?
Synaptic cleft
What are the two primary categories of neurotransmitters?
Inhibitory and excitatory
If an action potential is less likely to occur due to a neurotransmitter (in other words promotes the flow of potassium ions out of the neuron), what kind of NT is it?
Inhibitory
What do excitatory neurotransmitters do to a neuron?
Makes them more likely to fire as they promote the entrance of sodium ions into the neuron
Is it possible for any neurotransmitter to bind to any receptors? If so/not, explain why.
Due to the lock and key analogy, there is a degree of specifity between NT’s and receptors that prevents just any NT’s to bind to just any receptor
What are the two methods of neurotransmitter deactivation?
Reuptake and breakdown
Explain the process of neurotransmitter reuptake.
After detaching from the receptors, NT’s are reabsorbed into the pre-synaptic axon terminal
Explain the process of neurotransmitter breakdown.
After detaching from the receptors, NT’s are degraded by enzymes in the synaptic cleft
If a person is experiencing a seizure, what inferences can be made regarding the type of neurotransmitter that is predominantly acting?
That the NT’s are likely excitatory in nature
If a person stops breathing, what inferences can be made regarding the type of neurotransmitter that is predominantly acting?
That the NT’s are likely inhibitory in nature
What is cross talk and how is it prevented?
It is when a neuron is receiving inhibitory and excitatory signals but this is prevented as certain neurons contain either inhibitory or excitatory NT receptors (VERY BIG SIMPLIFCATION)
What is the difference between neuromodulators and neurotransmitters?
While neurotransmitters have very specific effects, neuromodulators have more generalized effects
If a drug is agonistic, what kind of effect does it have?
It promotes neurotransmitter activity
If a drug decreases neurotransmitter activity, what kind of drug is it?
Antagonistic
If we determine that a NT is involved with learning, can we (for certain) identify which neurotransmitter it is?
Likely not as almost all of the NT’s we will be dealing with are involved in learning
Which NT is most closely associated with Huntington’s disease? What kind of NT is it?
GABA, inhibitory
Other than learning, what else is glutamate involved in? What type of NT is it?
Memory, excitatory
Acetylcholine is a _________ type of NT and is most associated with __________.
excitatory, motor control
Botulistic bacteria can cause paralysis. Which NT do they most likely inhibit?
Acetylcholine
If there are increases in depression, and an increase in stress and panic disorders, which NT is most likely being reduced?
Norepinephrine
Which NT is most involved in reward, motivation, pleasurable feelings, and voluntary motor control?
Dopamine
What are SSRI’s and what are they thought to help with?
These are serotonin reuptake inhibitors that are thought to help with depression by increasing the time of mechanism by preventing reuptake into the pre-synaptic axon terminal