Chapter 27 To 27.2 Flashcards
What are amines
Amines are organic compounds that are derived from ammonia NH3, but here one or more hydrogens are replaced with a carbon ring or a Carbon chain
What’s the difference between aliphatic and aromatic amines
We just said amines are where hydrogens replaced with carbon ring or chain
Where it is attached to an aromatic ring r group it’s an aromatic amine
If just straight branched chain = aliphatic amine
How are amines classified (like everything else in chemistry)
Based on how many r groups of carbon chain/ Arya group is attached to the N makes it primary secondary or tertiary
How to name amines if they are primary
2 rules
And if they secondary tertiary same r group?
1) if it’s on carbon one, it just becomes chain amine = so like ethyl amine
2) if it’s not on carbon one but still primary, then say amino - position - chain
So like amino-2-propane means amine group is in the middle of the carbons
2) Just say di (r group) amine if it’s the same
If tertiary or secondary amines, how to name if DIFFERENT R GROUPS
(Rules)
Here you will need to do an N subsidised Of thr LARGER GROUP
- BASICALLY the largest group gets the suffix amine .
- any other group gets N- group to it, and if it’d tertiary then it will be N-group-N-group groupamine
- finally order which group comes first based on ALPHABET
That’s why it’s N-ethyl - N - methylpropylamine
Because propyl biggest so got amine, ethyl alphabetic so first!
How does amines act like a base and why?
What happens when they accept the proton
- what’s the charge!
Because we know a BL base is one that accepts protons, and here the amine having a nitrogen has a lone pair, and thus can accept a proton
When they accept the proton, the H+ forms a dative covalent bond .
- by conservation of charge itd now positive , accepting a proton increases positive charge by one
How do amines react with acids to produce
Why
What is produced
They produce a SINGLE SALT AND THATS IT
Why?
- because they act as bases so accept a proton, but then they can attach the the remaining negative ion , so the whole acid basically adds on
= one full addition reaction
What is similar to tje reaction between an amine and an acid
The reaction between ammonia and an acid
This is just an addition reaction, and amines being DERRIVATIVE will follow
With sn acid the hydrogen is only replaced by either a metal OR AMMONIUM ION, therefore this simple addition reaction happens
How to prepare primary amines what are the steps
This is done beginning with AMMONIA
As N has a lone pair , it can act as a nucleophile (donate a pair of electrons) to a haloalkane in a NUCLEOPHILIC ADDITION REACTION
1) so first the ammonia pure reacts with primary haloalkane. This forms a FULL SALT AGAIN In propylammonium chlroide
Now as it kinda got a hydrogen, it can react with alkali and give hydrogen to make water and chlroide ion react with something else
2) ammonium salt reacts with NaOH and forms NaCl and H2O alone with primary amine
This forms primary amine
What are the conditions for making exactly a primary amine and why (2)
1) is that Ethanol is used as the solvent so that halolakne doesn’t substitute with water to make alcohols instead
2) EXCESS ammonia used to LIMIT THR SMOUNT OF FURTHER SUBSTITION OF AMINE GROUP atoms form secondary and tertiary amines
Why is method to make primary amine not the bets for pure
Thus how can we make secondary and tertiary
Thr primary amine made can easily react with another halolakne as it still got lone pair to start process again
This is what happens 1) new primary amine reacts with halolakne addition to form ammonium chloride salt
2) reacts with more alkali to form di prohlamine whatever , Nacl and h2o
Can do it again ti make tertiary
For,action of primary secondary tertiary summarised
React with ammoni a haloalken in a NUCLEOPHILIC addition reaction to form an ammonium salt
2) this reacts with alkali ti form nacl h20 and amine
- for primary = ethanol to ensure water doesn’t substitute with the halolakne to form alcohol instead
- excess ammonia to prevent further substation of amine group to secondary tertiary
To make tertiary secondary react primary agsin with halolakne and do again
How to make aromatic amine
Say ohenylamine
JUST REMEMBER TWO STEPS AND PRODUCTS + Condtions
By reduction of nitrobenzene
1) happens by first heating nitrobenzene under reflex with tin and concentrated hydrochloride acid to form ammonium chloride salt
2) then reacted with excess NaOH to give the phenylamine and 2 water
Overall = nitrobenzene + 1) Sn/Conc HCl and 2) excess NaOH = phenylamine and 2h2o
Heated under reflux
What is an amino acid
Amino acid is anything with an amine group, a carboxylic acid, and a variable R group
The vernal formula for it is RCH(NH2)COOH
What are alpha and beta gamma amino acids briefly
Alpha amino acids is where the amine group attached to the second carbin of the chain , and these are the standard ones we have too
Beta is third and game 4th , don’t need to know
