Chapter 25 Depressive Disorders Flashcards
Depression
- One of the oldest and most frequently diagnosed psychiatric illnesses
- Mood changes
- Sadness, despair, and pessimism
- Loss of interest
- Possible changes in appetite, sleep patterns, or cognition
Epidemiology of Depression
- More prevalent in women than men
- Gender difference less significant between ages 44 and 65 years
- After age 65, more prevalent in women
- 2 to 1
Epidemiology: Social class
Inverse relationship between social class and report of depressive symptoms.
Epidemiology: Race and culture
No consistent relationship between race and affective disorder
Epidemiology: Marital status
Increased risk in single and divorced people
Biological Theories
- Heritability: estimated 40-50%
- Deficiency of norepinephrine, serotonin, and dopamine
- Excessive cholinergic treatment
Major Depressive Disorder (MDD)
- Depressed mood
- Loss of interest or pleasure in usual activities
- Symptoms present for at least 2 weeks
- Impaired social and occupational functioning
- No history of manic behavior
- Not attributed to use of substances or another medical condition
Major Depressive Disorder: DSM-V
- For atleast 2 weeks:
- Depressed mood
- and or - Markedly diminished interest or pleasure in all, or almost all, activities
- Depressed mood
Impairment in functioning
DSM-V MDD at least 5 of following symptoms
Depressed mood or irritability
Decreased interest or pleasure in activities
- Significant weight change (5%) or appetite changes
- Changes in sleep
- Change in activity
- Fatigue or loss of energy
- Guilt or worthlessness
- Concentration
- Suicidality
Mnemonic
Assessment: SIGECAPS
- Sleep disorder
- Interest deficit (anhedonia)
- Guilt
- Energy deficit
- Concentration deficit
- Appetite disorder, weight change
- Psychomotor retardation or agitation
- Suicidality
Dysthymic Disorder
- Mild
- Sad or “down in the dumps”
- No evidence of psychotic symptoms
- Chronically depressed mood for:
- Most of the day
- Most days
- At least 2 years
Premenstrual Dysphoric Disorder
- Depressed mood
- Anxiety
- Mood swings
- Decreased interest in activities
- Symptoms begin the week before menses
- improve within a few days after onset of menses
- Minimal or absent the week after menses
- improve within a few days after onset of menses
MDD Consequences
- Depression can be deadly
- Risk for suicide
- Emotional, cognitive, behavioral, and physical consequences
- Metabolic changes in the prefrontal cortex and limbic system (emotional brain)
- Structural changes in the hippocampus and prefrontal cortex
- Diminished neurotrophic support
Childhood Depression
< age 3: Feeding problems, tantrums, lack of playfulness and emotional expressiveness
Ages 3 to 5: Accident proneness, phobias, excessive self-reproach
Ages 6 to 8: Physical complaints, aggressive behavior, clinging behavior
Ages 9 to 12: Morbid thoughts and excessive worrying
What are examples of adolescent depression manifestations?
- Anger, aggressiveness
- Running away
- Delinquency
- Social withdrawal
- Sexual acting out
- Substance abuse
- Restlessness, apathy
- 2 to 3 weeks