chapter 25 antinflammatory drugs

Question 1

a response to tissue injury and infection

Answer 1

inflammation

Question 2

caused by microorganisms and results in inflammation, but NOT all inflammations are caused by this

Answer 2

infection

Question 3

the 5 cardinal signs of inflammation

Answer 3

redness, swelling (edema), heat, pain, and loss of function

Question 4

two phases of inflammation

Answer 4

vascular phase which occurs 10-15 mins after an injury and the delayed phase. The vascular phase is associated with vasodilation and increased capillary permeability, during which blood substances and fluid leave the plasma and go to the injured site. The delayed phase occurs when leukocytes infiltrate the inflamed tissue.

Question 5

chemical mediators

Answer 5

prostaglandins

Question 6

effects of prostaglandins

Answer 6

vasodilation, relaxation of smooth muscle, increased capillary permeability, and sensation of nerve cells to pain.

Question 7

enzyme responsible for converting ararchidonic acid into prostaglandins and their products

Answer 7

Cyclooxygenase (COX)

Question 8

protects the stomach lining and regulates blood platelets

Answer 8

COX 1

Question 9

triggers inflammation and pain

Answer 9

COX 2

Question 10

inhibit the biosynthesis of prostaglandins and affect the inflammatory process

Answer 10

prostaglandin inhibitors or anti-inflammatory agents

Question 11

relieve pain, reduce elevated blood pressure, inhibit platelet aggregation

Answer 11

anti-inflammatory agents

Question 12

oldest anti-inflammatory drug

Answer 12

aspirin